SML3082
Demethylwedelolactone
≥98% (HPLC)
동의어(들):
1,3,8,9-Tetrahydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one, 1,3,8,9-Tetrahydroxy-6H-benzofuro[3,2-c]chromen-6-one; 1,3,8,9-Tetrahydroxycoumestan, Desmethylwedelolactone, Norwedelolactone
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C15H8O7
CAS Number:
Molecular Weight:
300.22
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
![Benzo[a]pyrene ≥96% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/253/820/be96d879-1811-46c0-8f11-612019691c2d/640/be96d879-1811-46c0-8f11-612019691c2d.png)
Quality Level
분석
≥98% (HPLC)
형태
powder
색상
white to green
solubility
DMSO: 2 mg/mL, clear
저장 온도
−20°C
SMILES string
O=C1OC2=C(C(O)=CC(O)=C2)C3=C1C4=C(O3)C=C(O)C(O)=C4
InChI
1S/C15H8O7/c16-5-1-9(19)13-11(2-5)22-15(20)12-6-3-7(17)8(18)4-10(6)21-14(12)13/h1-4,16-19H
InChI key
LUTYTNLPIUCKBJ-UHFFFAOYSA-N
생화학적/생리학적 작용
Demethylwedelolactone is a coumestan extracted from Eclipta alba that exhibits numerous biological activities including anti-inflammatory and hepato-protective. Demethylwedelolactone inhibits MDA-MB-231 breast cancer cells motility and invasiveness. It suppresses the metastasis and lung colonization of the tumor cells in the nude mice. Both demethylwedelolactone and wedelolactone appear to attenuate cigarette smoking extract induced inflammation through blockade of autophagy flux in respiratory epithelial cells.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Shumin Ding et al.
Frontiers in pharmacology, 9, 107-107 (2018-03-09)
Excessive autophagy plays a crucial role in cigarette smoking extract (CSE)-induced inflammation response and oxidative damage of respiratory epithelial cells. The components from Eclipta prostrata L. (CCE) have been shown to be beneficial for CSE-induced epithelial cells injury. However, whether
K Satheesh Naik et al.
Maedica, 13(3), 217-222 (2019-09-07)
The hepatic injury due to oxidative stress was ameliorated through administration of an aqueous extract of Eclipta alba leaves and suggested that wedelolactone and demethylwedelolactone were the possible components of Eclipta alba behind the protective effect on liver as well
Yean-Jang Lee et al.
European journal of medicinal chemistry, 56, 361-367 (2012-08-29)
The anticancer properties of demethylwedelolactone (DWEL) and wedelolactone (WEL), which are naturally occurring coumestans, have not been well characterized. In this study, we investigated the anti-invasive effects of synthetic WEL and DWEL on human MDA-MB-231 breast cancer cells. We found
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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