SML3192
GLX481304
≥98% (HPLC)
동의어(들):
2-N-(3,4-Dimethylphenyl)-6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-1,3,5-triazine-2,4-diamine, N-(3,4-Dimethylphenyl)-6-[[4-(3-methoxyphenyl)-1-piperazinyl]methyl]-1,3,5-triazine-2,4-diamine, N2-(3,4-Dimethylphenyl)-6-[[4-(3-methoxyphenyl)-1-piperazinyl]methyl]-1,3,5-triazine-2,4-diamine, [4-Amino-6-[4-(3-methoxy-phenyl)-piperazin-1-ylmethyl]-1H-[1,3,5]triazin-2-ylidene]-(3,4-dimethyl-phenyl)-amine
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모든 사진(1)
About This Item
추천 제품
생화학적/생리학적 작용
GLX481304 is a cell-permeable, noncytotoxic triazine-diamino compound that acts a potent, dual NOX2 and NOX4 isoform-selective inhibitor (IC50 ~ 1.25 μM) over NOX1. Does neither function as an antioxidant nor as a scavenger of reactive oxygen species (ROS). GLX481304 is shown to dose-dependently reduce ROS levels in hypoxia challenged mouse cardiomyocytes and improve contractile function in whole heart.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Ferenc L M Szekeres et al.
Scientific reports, 11(1), 11970-11970 (2021-06-09)
The NADPH oxidase enzymes Nox2 and 4, are important generators of Reactive oxygen species (ROS). These enzymes are abundantly expressed in cardiomyocytes and have been implicated in ischemia-reperfusion injury. Previous attempts with full inhibition of their activity using genetically modified
Isabel Cordero-Herrera et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(1), 217-226 (2018-12-19)
Advanced age and unhealthy dietary habits contribute to the increasing incidence of obesity and type 2 diabetes. These metabolic disorders, which are often accompanied by oxidative stress and compromised nitric oxide (NO) signaling, increase the risk of adverse cardiovascular complications
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