N5751

N_ω-Nitro-L-arginine methyl ester hydrochloride

≥97% (TLC), powder, nitric oxide production inhibitor

• 동의어(들): L-NAME HCl, L-NAME hydrochloride
• 실험식(Hill 표기법): C₇H₁₅N₅O₄ · HCl
• CAS Number: 51298-62-5
• Molecular Weight: 269.69
• Beilstein: 3744166
• EC Number: 257-116-1
• MDL number: MFCD00039052
• UNSPSC 코드: 12352209
• PubChem Substance ID: 24278011
• NACRES: NA.77

속성

• product name: N_ω-Nitro-L-arginine methyl ester hydrochloride, ≥97% (TLC), powder
• 생물학적 소스: synthetic
• 분석: ≥97% (TLC)
• 형태: powder
• 색상: white to off-white
• mp: 132 °C
• solubility: H₂O: 50 mg/mL
• 저장 온도: −20°C
• SMILES string: Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O
• InChI: 1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
• InChI key: QBNXAGZYLSRPJK-JEDNCBNOSA-N

설명

일반 설명

Nω-Nitro-L-argininemethyl ester hydrochloride or L -NAME HCl, ananalog of arginine, inhibits NO production. It has multiple effects on thevascular system. Inhibits relaxation induced by acetylcholine and induces anincrease in arterial blood pressure. Abolishes lecithinized superoxidedismutase induced vasodilation when used to pretreat aortic ring preparationsof mice. Induces leukocyte adhesion and increases microvascular fluid andprotein fluxes and permeability. It has also been used in many studies oflearning and memory.

애플리케이션

Nω-Nitro-L-arginine methyl ester hydrochloride has been used:

• to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons
• to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin
• to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells
• to study its effect on the levels of arginine vasopressin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat

생화학적/생리학적 작용

Arginine analog that inhibits NO production.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)