SML3586

MU1700 dihydrochloride

≥98% (HPLC)

• 동의어(들): 6-(4-(Piperazin-1-yl)phenyl)-3-(quinolin-4-yl)furo[3,2-b]pyridine dihydrochloride
• 실험식(Hill 표기법): C₂₆H₂₂N₄O ·2HCl
• Molecular Weight: 479.40
• UNSPSC 코드: 12352200
• NACRES: NA.21

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• 저장 온도: 2-8°C

설명

생화학적/생리학적 작용

MU1700 is a potent and selective TGF-β type I receptors ALK1/ACVRL1 & ALK2/ACVR1 inhibitor (IC50 = 13/6 nM, [ATP] = 10 mM) that inhibits ALK6/BMPR1B only at higher concentrations (IC50 = 41 nM) with good kinome selectivity over >360 other kinases, including ALK3/BMPR1A (IC50 = 425 nM), ALK4/ACVR1B & ALK5/TGFBR1 (inactive). MU1700 inhibits cellular phospho-SMAD1/5/8 induction by 10 ng/mL BMP-7 and phospho-SMAD2 induction by either 10 ng/mL activin A or 100 ng/mL TGF-β1 with good target selectivity by cellular NanoBRET assays (ALK1/2 IC50 = 225/27 nM).

Potent and selective TGF-β type I receptors ALK1/ACVRL1 & ALK2/ACVR1 inhibitor.

주의사항

Hygroscopic

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable