481406

NF-κB Activation Inhibitor

The NF-κB Activation Inhibitor, also referenced under CAS 545380-34-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• 동의어(들): NF-κB Activation Inhibitor, 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
• 실험식(Hill 표기법): C₂₂H₂₀N₄O
• CAS Number: 545380-34-5
• Molecular Weight: 356.42
• MDL number: MFCD06411436
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: N(CCc3ccc(cc3)Oc4ccccc4)c1ncnc2c1cc(cc2)N
• InChI: 1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
• InChI key: IBAKVEUZKHOWNG-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable quinazoline compound that acts as a highly potent inhibitor of NF-κB transcriptional activation (IC₅₀ = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC₅₀ = 7 nM in murine splenocytes). Shown to exhibit anti-inflammatory effect on carrageenin-induced paw edema in rat. A 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481407) in DMSO is also available.

A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC₅₀ = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC₅₀ = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
NF-κB transcriptional activation

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 11 nM against NF-κB transcriptional activation in Jurkat cells

포장

Packaged under inert gas

경고

Toxicity: Toxic (F)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Tobe, M., et al. 2003. Bioorg. Med. Chem.11, 383.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3