654255

TNF-α Antagonist

≥95% (HPLC), lyophilized, TNF-α antagonist, Calbiochem^®

• 동의어(들): TNF-α Antagonist, TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
• 실험식(Hill 표기법): C₅₈H₇₁N₁₁O₁₅S₂
• Molecular Weight: 1226.38
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 제품명: TNF-α Antagonist, The TNF-α Antagonist controls the biological activity of TNF-α.
• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: lyophilized
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• solubility: water: 1 mg/mL; 5% acetic acid: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.

생화학적/생리학적 작용

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 5 µM as TNF-α antagonist

경고

Toxicity: Standard Handling (A)

서열

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)

기타 정보

Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.

법적 정보

Sold under license of U.S. Patent 6,265,535.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable