654257

TNF-α Antagonist III, R-7050

The TNF-α Antagonist III, R-7050, also referenced under CAS 303997-35-5, controls the biological activity of TNF-α.

• 동의어(들): TNF-α Antagonist III, R-7050, 8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline
• 실험식(Hill 표기법): C₁₆H₈ClF₃N₄S
• CAS Number: 303997-35-5
• Molecular Weight: 380.77
• MDL number: MFCD00140737
• UNSPSC 코드: 51111800
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: light yellow
• solubility: DMSO: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: FC(F)(F)c1[n]2c(nn1)c(nc4c2cc(cc4)Cl)Sc3ccccc3
• InChI: 1S/C16H8ClF3N4S/c17-9-6-7-11-12(8-9)24-13(22-23-15(24)16(18,19)20)14(21-11)25-10-4-2-1-3-5-10/h1-8H
• InChI key: SUUMKHOVGVYGOP-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable triazoloquinoxaline compound that acts as a TNF-α receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-α ligand-receptor binding. Shown to selectively inhibit TNF-α-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-α-induced than IL-1β-induced NF-κB activation (EC₅₀ = 0.631 and 1.45 µM, respectively) in A549 cells.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Gururaja, T.L., et al. 2007. Chem. Biol.14, 1105.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable