추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥98% (HPLC)
≥98% (SDS-PAGE)
형태
lyophilized
분자량
20.2 kDa
포장
pkg of 100 μg
기술
cell culture | mammalian: suitable
불순물
<0.1 EU/μg endotoxin, tested
색상
white to off-white
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... COL18A1(80781)
일반 설명
Research area: Cell Signaling
Endostatin is an endogenous glycoprotein derived from the C-terminal portion of the α1 chain of type XVIII collagen. It is encoded by the gene mapped to human chromosome 21q22.3. Recombinant human Endostatin protein consists of 184 amino acid residues. It is expressed in various organs with the highest levels in liver, lung, and kidney.
Endostatin is an endogenous glycoprotein derived from the C-terminal portion of the α1 chain of type XVIII collagen. It is encoded by the gene mapped to human chromosome 21q22.3. Recombinant human Endostatin protein consists of 184 amino acid residues. It is expressed in various organs with the highest levels in liver, lung, and kidney.
생화학적/생리학적 작용
Endostatin is a potent inhibitor of angiogenesis. It exerts its angiostatic effect through multiple pathways related to endothelial cell migration and proliferation. Endostatin inhibits and suppresses the actions of matrix metalloproteinases (MMPs), FAK (Focal adhesion kinase)/Ras/p38-MAPK (mitogen-activated protein kinase)/ERK (extracellular signal-regulated kinase) signaling cascade, HIF-1α(hypoxia-inducible factor 1 alpha)/VEGF-A (vascular endothelial growth factor)thereby inhibiting angiogenesis by preventing the migration and invasion of endothelial cells. Endostatin also blocks the apoptosis of cells and the G1 to S phase transition in the cell cycle. Mutations in this gene lead to Knobloch syndrome (KS), a rare autosomal recessive disorder.
서열
MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK
물리적 형태
Lyophilized from 10 mM Sodium Phosphate, pH 7.5.
재구성
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
A V Digtyar et al.
Biochemistry. Biokhimiia, 72(3), 235-246 (2007-04-24)
Endogenous inhibitors of angiogenesis are proved to be a major factor preventing the emergence of clinically manifested stages of human cancer. The protein endostatin, a 20-kD proteolytic fragment of type XVIII collagen, is one of the most active natural inhibitors
S P Oh et al.
Genomics, 19(3), 494-499 (1994-02-01)
Types XV and XVIII collagen belong to a unique and novel subclass of the collagen superfamily for which we have proposed the name the MULTIPLEXIN family. Members of this class contain polypeptides with multiple triple-helical domains separated and flanked by
Extracellular matrix modulates angiogenesis in physiological and pathological conditions.
Neve A
BioMed Research International, 756078-756078 (2014)
Maria Rita Passos-Bueno et al.
Anais da Academia Brasileira de Ciencias, 78(1), 123-131 (2006-03-15)
Collagen XVIII, a proteoglycan, is a component of basement membranes (BMs). There are three distinct isoforms that differ only by their N-terminal, but with a specific pattern of tissue and developmental expression. Cleavage of its C-terminal produces endostatin, an inhibitor
Ilkka Alahuhta et al.
Experimental cell research, 336(1), 130-140 (2015-06-27)
The turnover of extracellular matrix liberates various cryptic molecules with novel biological activities. Endostatin is an endogenous angiogenesis inhibitor that is derived from the non-collagenous domain of collagen XVIII. Although there are a large number of studies on its anti-tumor
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