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Merck
모든 사진(1)

Key Documents

SRP6158

Sigma-Aldrich

EPO human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

동의어(들):

EP, EPO-alpha, Epoetin, Erythropoietin-alpha, MGC138142

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About This Item

CAS Number:
UNSPSC 코드:
12352202
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in HEK 293 cells

분석

≥95% (SDS-PAGE)

형태

lyophilized

분자량

36 kDa (monomer, glycosylated)

포장

pkg of 10 μg

기술

cell culture | mammalian: suitable

NCBI 수납 번호

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... EPO(2056)

일반 설명

The gene EPO (erythropoietin) is mapped to human chromosome 7q22. It is a glycoprotein hormone. EPO is generated in fetal liver and adult kidney. However, it can also be secreted by other organs, such as the heart, brain and lungs. EPO is a member of the EPO/TPO (thrombopoietin) family and is found in the plasma.

애플리케이션

  • EPO (erythropoietin) has been used as a component of the culture medium for cardiac stem cells.
  • In cultured cerebellar granule cells and hippocampal neurons, it has been used to study effect of EPO on glutamate release.
  • It has also been used as a component of endothelial differentiation medium.

생화학적/생리학적 작용

EPO (erythropoietin) regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. It interacts with EPO receptor and is responsible for the cellular responses. EPO is expressed in many cancers, including breast cancer, renal cancer, gastric cancer, hepatocellular carcinoma and central nervous system tumors. In addition, it is a hypoxia responsive cytokine and a pro-angiogenic factor. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. It can protect from brain damages due to ischemia and enhances memory as well as cognitive ability in humans suffering from vascular dementia.

물리적 형태

Lyophilized from a PBS solution.

제조 메모

Centrifuge the vial prior to opening.

재구성

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

이미 열람한 고객

Identification of human chronic myelogenous leukemia progenitor cells with hemangioblastic characteristics.
Fang B, et al.
Blood, 105, 2733-2740 (2005)
Beth J Allison et al.
Journal of applied physiology (Bethesda, Md. : 1985), 126(1), 44-50 (2018-11-02)
Erythropoietin (EPO) is being trialled in preterm infants to reduce brain injury, but high doses increase lung injury in ventilated preterm lambs. We aimed to determine whether early administration of lower doses of EPO could reduce ventilation-induced lung injury and
Tessa Wilkin et al.
Drug testing and analysis, 9(9), 1456-1471 (2017-03-30)
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Luis Toro et al.
Kidney international, 93(5), 1131-1141 (2018-02-06)
It is accepted that osteoblasts/osteocytes are the major source for circulating fibroblast growth factor 23 (FGF23). However, erythropoietic cells of bone marrow also express FGF23. The modulation of FGF23 expression in bone marrow and potential contribution to circulating FGF23 has
Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia.
Kawakami M, et al.
The Journal of Biological Chemistry, 276, 39469-39475 (2001)

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