SRP8054

Tim-1 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• 동의어(들): Hepatitis A virus cellular receptor 1, KIM1, T-cell immunoglobulin and mucin domain-containing protein 1, T-cell immunoglobulin and mucin domain-containing protein 4, TIMD1
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 생물학적 소스: human
• 재조합: expressed in CHO cells
• 분석: ≥98% (SDS-PAGE)
• 형태: lyophilized
• 분자량: monomer 57 kDa by calculation
• 포장: pkg of 100 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 불순물: <0.06 EU/μg endotoxin, tested
• 색상: white
• UniProt 수납 번호: Q96D42
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... HAVCR1(26762)

설명

일반 설명

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

물리적 형태

Lyophilized from 0.2 μm-filtered solution in PBS.

재구성

Reconstitute at 100 μg/mL in sterile PBS.

기타 정보

The extracellular domain of human Tim-1 (aa 21-295) is fused to the N-terminus of the Fc region of human IgG1.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable