T1573

Thrombin Receptor Activator Peptide 6

>95% (HPLC)

• 동의어(들): TRAP-6
• 실험식(Hill 표기법): C₃₄H₅₆N₁₀O₉
• CAS Number: 141136-83-6
• Molecular Weight: 748.87
• MDL number: MFCD00238172
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329826680
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: >95% (HPLC)
• 양식: lyophilized
• 기술: cell culture | mammalian: suitable
• solubility: 0.1% TFA: soluble; water: soluble
• UniProt 수납 번호: P25116
• 저장 온도: −20°C
• SMILES string: CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O
• InChI: 1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1
• InChI key: HAGOWCONESKMDW-FRSCJGFNSA-N
• 유전자 정보: human ... F2R(2149)

설명

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn

일반 설명

Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.

애플리케이션

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).

생화학적/생리학적 작용

Hexapeptide fragment of the thrombin receptor (residues 42-47).

Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC₅₀ = 0.8 μM).

기타 정보

Lyophilized from 0.1% TFA in H2O

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)