T3125

Tetrahydrofolic acid

≥65% (when packaged), powder

• 동의어(들): 5,6,7,8-Tetrahydropteroyl-L-glutamic acid, THF
• 실험식(Hill 표기법): C₁₉H₂₃N₇O₆
• CAS Number: 135-16-0
• Molecular Weight: 445.43
• Beilstein: 9238187
• EC Number: 205-181-1
• MDL number: MFCD00135583
• UNSPSC 코드: 12352204
• PubChem Substance ID: 24900106
• NACRES: NA.51

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 양식: powder
• 농도: ≥65% (when packaged)
• 색상: faintly yellow to light brown
• solubility: 0.1 M phosphate pH 7.0: soluble-5 mg/mL, clear to slightly hazy, light yellow to brownish-yellow
• 저장 온도: −20°C
• SMILES string: NC1=NC2=C(NC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1
• InChI: 1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1
• InChI key: MSTNYGQPCMXVAQ-KIYNQFGBSA-N

설명

애플리케이션

Tetrahydrofolic acid has been used to determine the inhibitory effect of tetrahydrofolate on polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). A recent use of tetrahydrofolate (THF) is for studying the activation of riboswitches.

Tetrahydrofolic acid may also be used as a standard to generate calibration curve to quantify the folate types produced by Streptococcus thermophilus in milk cultures using high-performance liquid chromatography (HPLC). It is also suitable for use in the enzymatic assay of formate-tetrahydrofolate ligase from M. extorquens (MeFtfL).

생화학적/생리학적 작용

Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolate metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids

포장

Sealed ampule.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)