F7876

Folic acid

≥97%

• 동의어(들): PteGlu, Pteroyl-L-glutamic acid, Vitamin M
• 실험식(Hill 표기법): C₁₉H₁₉N₇O₆
• CAS Number: 59-30-3
• Molecular Weight: 441.40
• Beilstein: 100781
• EC Number: 200-419-0
• MDL number: MFCD00079305
• UNSPSC 코드: 12352106
• eCl@ss: 34058014
• PubChem Substance ID: 57654192
• NACRES: NA.79

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥97%
• 형태: powder
• 기술: HPLC: suitable
• 색상: faint orange to dark orange-yellow; faint yellow to dark yellow
• mp: >285 °C
• 저장 온도: room temp
• SMILES string: NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
• InChI: 1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
• InChI key: OVBPIULPVIDEAO-LBPRGKRZSA-N

설명

애플리케이션

Folic acid has been used:

• to induce acute kidney injury in mice
• as a supplement to cultivate MCF-7 breast cancer cells.
• to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles

생화학적/생리학적 작용

Enzyme cofactor essential for the synthesis, methylation, and repair of DNA. Folic acid supplements may reduce colorectal cancer risk.

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)