T3580

Toyocamycin

≥98% (HPLC), from Streptomyces rimosus

• 동의어(들): 4-Aminopyrrolo[2,3-d]pyrimidine-5-carbonitrile 7-(β-D-ribofuranoside), 7-Deaza-7-cyanoadenosine, NSC 63701, NSC 99843, Neuro 000027, Unamycin B, Vengicide
• 실험식(Hill 표기법): C₁₂H₁₃N₅O₄
• CAS Number: 606-58-6
• Molecular Weight: 291.26
• MDL number: MFCD00866513
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329826772
• NACRES: NA.77

속성

• 생물학적 소스: Streptomyces rimosus
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 형태: solid
• solubility: DMSO: soluble 0.90-1.10 mg/mL, clear, colorless; H₂O: moderately soluble; aqueous acid: moderately soluble; ethanol: moderately soluble; methanol: moderately soluble
• 항생제 활성 스펙트럼: fungi
• 동작 모드: DNA synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: Nc1ncnc2n(cc(C#N)c12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• InChI: 1S/C12H13N5O4/c13-1-5-2-17(11-7(5)10(14)15-4-16-11)12-9(20)8(19)6(3-18)21-12/h2,4,6,8-9,12,18-20H,3H2,(H2,14,15,16)/t6-,8-,9-,12-/m1/s1
• InChI key: XOKJUSAYZUAMGJ-WOUKDFQISA-N

설명

생화학적/생리학적 작용

Studies have implicated that toyocamycin blocks the replication of fowl plague virus.

Toyocamycin is a nucleoside- type antibiotic analogue of adenosine, isolated from Streptomyces species. Toyocamycin is an anti-tumor antibiotic with various target activities. Toyocamycin is a potent inhibitor of RNA self-cleavage in mammalian cells. It also inhibits phosphatidylinositol kinase, a cell proliferation regulator. Toyocamycin was also found to inhibit Auxin signaling. Auxins are plant hormones with a crucial role in plant development regulation, and Toyocamycin was found to specifically inhibit auxin-responsive gene expression.

특징 및 장점

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

Toyocamycin is soluble in DMSO at 0.90 - 1.10 mg/ml and yields a clear, colorless solution. It is also soluble in acidic solutions and is moderately soluble in water, methanol and ethanol. Solutions prepared in DMSO can be diluted 10-fold in water.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable