T6950
Tizanidine hydrochloride
≥98% (HPLC), powder
동의어(들):
5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C9H9Cl2N5S
CAS Number:
Molecular Weight:
290.17
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
색상
white
solubility
H2O: >20 mg/mL
주관자
Acorda Therapeutics
SMILES string
Cl[H].Clc1ccc2nsnc2c1NC3=NCCN3
InChI
1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H
InChI key
ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
유전자 정보
human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
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애플리케이션
Tizanidine hydrochloride has been used for developing spectrophotometric methods for the validation of skeletal muscle relaxants.
생화학적/생리학적 작용
α2-adrenoceptor agonist.
Tizanidine hydrochloride is known to function as a skeletal muscle relaxant that acts centrally. Furthermore, this relaxant functions at spinal and supraspinal levels to block excitatory interneurons. This drug is used for the symptomatic relief of spasticity and painful muscle spasms.
특징 및 장점
This compound was developed by Acorda Therapeutics. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
제조 메모
Tizanidine hydrochloride is soluble in water at a concentration that is greater than 20 mg/ml.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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시험 성적서(COA)
Lot/Batch Number
Tomoyuki Kawamata et al.
Anesthesiology, 98(6), 1480-1483 (2003-05-27)
Although intrathecal clonidine produces pronounced analgesia, antinociceptive doses of intrathecal clonidine produce several side effects, including hypotension, bradycardia, and sedation. Intrathecal tizanidine, another alpha(2)-adrenergic agonist, has provided antinociception without producing pronounced hemodynamic changes in animal studies. However, it has been
Mohamed I Walash et al.
Chemistry Central journal, 5, 60-60 (2011-10-11)
A simple, sensitive and rapid spectrophotometric method was developed and validated for the determination of two skeletal muscle relaxants namely, tizanidine hydrochloride (I) and orphenadrine citrate (II) in pharmaceutical formulations. The proposed method is based on the formation of a
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