추천 제품
생물학적 소스
synthetic (organic)
Quality Level
분석
≥98%
양식
powder
효능
0.8 μM IC50
solubility
DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red
저장 온도
2-8°C
SMILES string
NC(\C(=C\c1cc(O)c(O)c(O)c1)C#N)=C(/C#N)C#N
InChI
1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,18-20H,17H2/b8-1+
InChI key
JKNOYWVMHPMBEL-UNXLUWIOSA-N
유전자 정보
human ... CDK2(1017) , EGFR(1956)
애플리케이션
Tyrphostin 51 has been used to study the inhibition of rat hepatic leptin 1.
생화학적/생리학적 작용
Tyrphostin 51 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
EGFR tyrosine kinase inhibitor.
특징 및 장점
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
제조 메모
5 mg of Tyrphostin 51 is soluble in 0.1 ml of DMSO and yields a clear, orange to red solution.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Shah M Khan et al.
The Journal of clinical endocrinology and metabolism, 90(1), 469-473 (2004-10-21)
Growth factors may be involved in the control of ovarian cell fate and could contribute to regulation of ovarian cell apoptosis. Our objective is to test the hypothesis that, in human luteinized granulosa cells, epidermal growth factor (EGF) works through
P Yaish et al.
Science (New York, N.Y.), 242(4880), 933-935 (1988-11-11)
A systematic series of low molecular weight protein tyrosine kinase inhibitors were synthesized; they had progressively increasing affinity over a 2500-fold range toward the substrate site of epidermal growth factor (EGF) receptor kinase domain. These compounds inhibited EGF receptor kinase
A Gazit et al.
Journal of medicinal chemistry, 32(10), 2344-2352 (1989-10-01)
A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the substrate site of the EGF receptor kinase domain. These competitive inhibitors
문서
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
관련 콘텐츠
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