추천 제품
product name
Astec® CHIROBIOTIC® T Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
material
stainless steel column
Quality Level
Agency
suitable for USP L63
설명
HPLC column
제품 라인
Astec®
포장
pkg of 1 ea
제조업체/상표
Astec®
파라미터
0-45 °C temperature
241 bar pressure (3500 psi)
기술
HPLC: suitable
LC/MS: suitable
길이 × I.D.
10 cm × 4.6 mm
기질
High-purity silica gel particle platform
fully porous particle
기질 활성군
teicoplanin glycopeptide phase
입자 크기
5 μm
공극 크기
100 Å
operating pH range
3.8-6.8
분리 기술
chiral
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
CHIROBIOTIC® T and T2 have teicoplanin as the chiral selector. They offer unique selectivity for a number of classes of molecules, specifically underivatized α, β, γ and cyclic amino acids, N-derivatized amino acids, hydroxy-carboxylic acids, acidic compounds including carboxylic acids and phenols, small peptides, neutral aromatic analytes and cyclic aromatic and aliphatic amines. Separations normally obtained on a chiral crown ether or ligand exchange-type CSPs are also possible on the CHIROBIOTIC® T and T2, but in much simpler mobile phases, like water-alcohol. In addition, all of the known beta-blockers (amino alcohols), and dihydrocoumarins have been resolved. CHIROBIOTIC® T and T2 differ in their bonding chemistry and the pore size of the support particle, giving them different selectivity and preparative capacity.
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
- Bonded phase: Teicoplanin
- Operating pH range: 3.8 - 6.8
- Particle diameter: 5, 10 or 16 μm
- Pore size: 100 Å (CHIROBIOTIC® T) or 200 Å (CHIROBIOTIC® T2)
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
애플리케이션
- Chiral liquid chromatography-mass spectrometry (LC-MS/MS) method development for the detection of salbutamol in urine samples.: This study utilizes the Astec CHIROBIOTIC T Chiral HPLC Column to develop an LC-MS/MS method for detecting and quantifying salbutamol enantiomers in urine samples. This application demonstrates the column′s utility in biomedical and clinical research, particularly in the analysis of chiral drugs in biological matrices (Chan et al., 2016).
- High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: This research focuses on the enantioseparation of various amino acids using the Astec CHIROBIOTIC T Chiral HPLC Column, highlighting its effectiveness in separating complex chiral molecules. The study underscores the column′s application in the enantioselective analysis of amino acids and related compounds in chemical and pharmaceutical research (Berkecz et al., 2009).
법적 정보
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Berit P Jensen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 865(1-2), 48-54 (2008-03-07)
A stereoselective liquid chromatography-tandem mass spectrometry assay was developed and validated for quantification of S- and R-metoprolol at concentrations of 0.5-50 microg/L in human plasma. Metoprolol was extracted from plasma by liquid-liquid extraction with ethyl acetate (82% recovery). Chromatographic separation
D Abd el-Hady et al.
Journal of pharmaceutical and biomedical analysis, 37(5), 919-925 (2005-05-03)
A simple, sensitive and selective high performance liquid chromatographic method with UV detection for the chiral separation of racemic methotrexate (rac-Mtx) and enantiomeric purity of L-methotrexate in pharmaceutical formulations was developed and validated. The chiral separation was optimized studying both
Yuan-Qing Xia et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 788(2), 317-329 (2003-04-23)
An automated online sample extraction method for rat plasma was developed and validated for the quantification of (R)- and (S)-propranolol following the intravenous administration of either the racemate or the individual enantiomers at 5 mg/kg. A dual-column extraction system coupled
Syntheses of racemic and non-racemic silicon- and germanium-containing a-amino acids of the formula type H2NCH(CH2ElR3)COOH (El=Si, Ge; R=organyl) and incorporation of d-H2NCH(CH2SiMe3)COOH and d-H2NCH(CH2GeMe3)COOH into biologically active decapeptides: a study on C/Si/Ge bioisosterism
Merget, Markus, et al.
Journal of Organometallic Chemistry, 628 (2), 183-194 (2001)
Balázs Visegrády et al.
Journal of biochemical and biophysical methods, 53(1-3), 15-24 (2002-10-31)
This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R) and teicoplanin (Chirobiotic T) phases. All columns showed good chiral recognition ability for this class of compounds. Out
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