15022AST

Astec^® CHIROBIOTIC^® V2 Chiral (5 μm) HPLC Columns

L × I.D. 10 cm × 4.6 mm, HPLC Column

• 동의어(들): CHIROBIOTIC V2 Chiral Chromatography Column
• UNSPSC 코드: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

속성

• 제품명: Astec^® CHIROBIOTIC^® V2 Chiral HPLC Column, 5 μm particle size, L × I.D. 10 cm × 4.6 mm
• material: stainless steel column
• Quality Level: 100
• Agency: suitable for USP L88
• 설명: HPLC column
• 제품 라인: Astec^®
• 포장: pkg of 1 ea
• 제조업체/상표: Astec^®
• 파라미터: 0-45 °C temperature; 241 bar pressure (3500 psi)
• 기술: HPLC: suitable; LC/MS: suitable
• 길이 × I.D.: 10 cm × 4.6 mm
• Matrix: High-purity silica gel particle platform; fully porous particle
• 기질 활성군: vancomycin phase
• 입자 크기: 5 μm
• 공극 크기: 200 Å
• 작동 pH 범위: 3.5-7.0
• 분리 기술: chiral

설명

일반 설명

Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC^® V in the polar ionic mode. The CHIROBIOTIC^® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC^® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.

• Bonded phase: Vancomycin
• Operating pH range: 3.5 - 7.0
• Particle diameter: 5, 10 or 16 μm
• Pore size: 100 Å (CHIROBIOTIC^® V) or 200 Å (CHIROBIOTIC^® V2)

CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature

애플리케이션

• Chiral analysis of dextromethorphan and levomethorphan in human hair by liquid chromatography-tandem mass spectrometry: This study utilized the CHIROBIOTIC^® V2 column to achieve chiral separation of dextromethorphan and levomethorphan in human hair, highlighting the column′s application in forensic toxicology for precise enantiomeric analysis (Ji et al., 2022).


• Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma: This research demonstrates the application of CHIROBIOTIC^® V2 for pharmacokinetic studies in rats, establishing a method for enantioselective determination that can be crucial for drug development and therapeutic monitoring (Zhang et al., 2016).


• New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase: The use of CHIROBIOTIC^® V2 column in developing a new HPLC method for the separation of warfarin enantiomers underscores its utility in clinical analysis and therapeutic drug monitoring, showing its broad applicability in biomedical research (Malakova et al., 2009).

추천 제품

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

법적 정보

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany

CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC