Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing.

Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing.

Molecules (Basel, Switzerland) (2015-10-02)

Thomas M Kohl, Christian H Hornung, John Tsanaktsidis

초록

Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers.

MATERIALS

제품 번호

브랜드

제품 설명

606723

Sigma-Aldrich

Methanol-¹²C, 99.95 atom % ¹²C

723851

Supelco

Dichloromethane solution, contains 10 % (v/v) methanol

721956

Sigma-Aldrich

Methanol solution, NMR reference standard, 4% in methanol-d₄ (99.8 atom % D), NMR tube size 3 mm × 8 in.

270997

Sigma-Aldrich

Dichloromethane, anhydrous, ≥99.8%, contains 40-150 ppm amylene as stabilizer

278475

Sigma-Aldrich

2-Propanol, anhydrous, 99.5%

276855

Sigma-Aldrich

Dimethyl sulfoxide, anhydrous, ≥99.9%

74875

Sigma-Aldrich

8-Octanoyloxypyrene-1,3,6-trisulfonic acid trisodium salt, suitable for fluorescence, ≥90% (HPCE)

108987

Sigma-Aldrich

Methyl 3-mercaptopropionate, 98%

B80429

Sigma-Aldrich

4-Bromopyridine hydrochloride, 99%

59300

Sigma-Aldrich

2-Propanol, puriss. p.a., ACS reagent, ≥99.8% (GC)

I9516

Sigma-Aldrich

2-Propanol, for molecular biology, BioReagent, ≥99.5%

59304

Sigma-Aldrich

2-Propanol, BioUltra, for molecular biology, ≥99.5% (GC)

I9030

Sigma-Aldrich

Isopropyl alcohol, meets USP testing specifications

109827

Sigma-Aldrich

2-Propanol, Laboratory Reagent, ≥99.5%

190764

Sigma-Aldrich

2-Propanol, ACS reagent, ≥99.5%

D2650

Sigma-Aldrich

Dimethyl sulfoxide, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

632546

Supelco

Methanol solution, contains 0.10 % (v/v) formic acid, UHPLC, suitable for mass spectrometry (MS), ≥99.5%

D8418

Sigma-Aldrich

Dimethyl sulfoxide, for molecular biology

D9170

Sigma-Aldrich

Dimethyl sulfoxide, PCR Reagent

D1435

Sigma-Aldrich

Dimethyl sulfoxide, meets EP testing specifications, meets USP testing specifications

D5879

Sigma-Aldrich

Dimethyl sulfoxide, ReagentPlus^®, ≥99.5%

D4540

Sigma-Aldrich

Dimethyl sulfoxide, ≥99.5% (GC), suitable for plant cell culture

41639

Sigma-Aldrich

Dimethyl sulfoxide, BioUltra, for molecular biology, ≥99.5% (GC)

D2438

Sigma-Aldrich

Dimethyl sulfoxide, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

32222

Sigma-Aldrich

Dichloromethane, puriss. p.a., ACS reagent, reag. ISO, ≥99.9% (GC)

472301

Sigma-Aldrich

Dimethyl sulfoxide, ACS reagent, ≥99.9%

494453

Sigma-Aldrich

Dichloromethane, biotech. grade, 99.9%, contains 40-150 ppm amylene as stabilizer

D65100

Sigma-Aldrich

Dichloromethane, contains 40-150 ppm amylene as stabilizer, ACS reagent, ≥99.5%

320269

Sigma-Aldrich

Dichloromethane, ACS reagent, ≥99.5%, contains 40-150 ppm amylene as stabilizer

33539

Sigma-Aldrich

2-Propanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8% (GC)