MilliporeSigma

ESR2

estrogen receptor 2 (ER beta)

Synonyms:
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Species:
UniProtKB ID:
Gene ID:
  • Human(2100) Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13983) estrogen receptor 2 (beta)
  • Rat(25149) estrogen receptor 2 (ER beta)
  • dog(403639) estrogen receptor 2 (ER beta)
  • chicken(395575) estrogen receptor 2 (ER beta)
  • domestic guinea pig(100731304) estrogen receptor 2 (ER beta)
  • Domestic Rabbit(100346748) estrogen receptor 2 (ER beta)
  • domestic cat(101086317) estrogen receptor 2 (ER beta)
  • Horse(100033964) estrogen receptor 2 (ER beta)
  • cow(281146) estrogen receptor 2 (ER beta)
  • Goat(100860823) estrogen receptor 2 (ER beta)
  • sheep(443066) estrogen receptor 2 (ER beta)

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Small Molecule - Activator

Product Number
Description
Species
β-Nicotinamide adenine dinucleotide hydrate, ≥95% (HPLC),
Species
human
β-Nicotinamide adenine dinucleotide lithium salt from Saccharomyces cerevisiae, ≥95%,
Species
human
β-Nicotinamide adenine dinucleotide hydrate, suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Species
human
β-Nicotinamide adenine dinucleotide hydrate, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Species
human
β-Nicotinamide adenine dinucleotide hydrate, BioUltra, ≥98%, from yeast,
Species
human

Small Molecule - Agonist

Product Number
Description
Species
ERB-041, ≥98% (HPLC),
Species
human
4-{1-Ethyl-2-[4-(phosphonooxy)phenyl]-1-butenyl}phenyl dihydrogen phosphate, ,
Species
human
17α-Ethynylestradiol 3-cyclopentyl ether, ,
Species
human
Estrone, ≥99%,
Species
human, mouse, rat

Small Molecule - Allosteric Modulator

Product Number
Description
Species
Raloxifene hydrochloride for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Raloxifene hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
Raloxifene Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Raloxifene hydrochloride, solid,
Species
human
Estramustine sodium phosphate, ,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
2-Methoxyestradiol, powder,
Species
human
Fulvestrant, United States Pharmacopeia (USP) Reference Standard,
Species
human
Fulvestrant, European Pharmacopoeia (EP) Reference Standard,
Species
human
Fulvestrant for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Fulvestrant, >98% (HPLC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ESR2 antibody produced in mouse, ,
Species Reactivity
human, monkey, mouse
Application
ChIP
dot blot

flow cytometry

immunocytochemistry

immunofluorescence

immunohistochemistry

western blot
Anti-phospho-Estrogen Receptor-? (pSer87) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
Anti-phospho-Estrogen Receptor-β (pSer105) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-ESR2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, human, mouse, pig, rat
Application
western blot
Monoclonal Anti-ESR2 antibody produced in mouse, clone 3F3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot

Cell Lines

Product Number
Description
Species
MCF10A CELLS ESR2 (-/-), ,
Species
human

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
α-Estradiol, powder, ≥98% (TLC),
Species
human, rat
Estradiol, meets USP testing specifications,
Species
human, mouse, rat
Progesterone-Water Soluble, powder, BioReagent, suitable for cell culture,
Species
mouse, human, rat
β-Estradiol, powder, γ-irradiated, suitable for cell culture,
Species
human, mouse, rat
β-Estradiol, analytical standard,
Species
human, mouse, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human ESR2,
Species
human