ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Synonyms:
ABC30, CMOAT, DJS, MRP2, cMRP
Species:
Human ABCC2 (1244), Mouse Abcc2 (12780), Rat Abcc2 (25303), sheep ABCC2 (101119776), Horse ABCC2 (100060654), naked mole-rat Abcc2 (101716089), domestic guinea pig Abcc2 (100718828), cow ABCC2 (520925), domestic cat ABCC2 (101085924), dog ABCC2 (403632) ...More
UniProtKB ID:
Gene ID:
- Human(1244) Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
- Mouse(12780) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- Rat(25303) ATP-binding cassette, subfamily C (CFTR/MRP), member 2
- sheep(101119776) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- Horse(100060654) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- naked mole-rat(101716089) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- domestic guinea pig(100718828) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- cow(520925) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- domestic cat(101085924) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- dog(403632) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- chicken(423828) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- Zebrafish(393561) ATP-binding cassette, sub-family C (CFTR/MRP), member 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ABCC2 antibody produced in mouse, clone 2H6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-MRP2 Antibody, clone 4C9.2, clone 4C9.2, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-MRP2 Antibody, clone M2 I-4, culture supernatant, clone M2 I-4, Chemicon®,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MRP2 antibody, Mouse monoclonal, clone CPR96, purified from hybridoma cell culture,
Species Reactivity
human
Application
ELISA
microarray
western blot
microarray
western blot
Anti-MRP2 Antibody, clone 1B2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Cell Lines
Product Number
Description
Species
Kits
Product Number
Description
Species
Proteins
Product Number
Description
Species
SB-MRP2-Sf9-PREDEASY-ATPase kit, membrane based kit for Human MRP2 ATPase Transport Assays,
Species
human
SB-MRP2-Sf9, membrane preparation for Vesicular Transport Assays, recombinant, expressed in baculovirus infected Sf9 cells,
Species
human
esiRNA
Product Number
Description
Species