MTOX1006
BCRP/MRP2 Double Knockout Caco-2 Cells
Human male colorectal tissue, adenocarcinoma
Synonym(s):
C2BBe1 Cells BCRP/MRP2 (-/-/-/-,-/-/-/-)
About This Item
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product name
BCRP/MRP2 Double Knockout Caco-2 Cells, one vial
biological source
human male colorectal tissue (Source disease: adenocarcinoma)
form
liquid
technique(s)
drug transporter assay: suitable
permeability assay: suitable
application(s)
ADME/TOX
storage temp.
−196°C
Gene Information
human ... ABCC2(1244) , ABCG2(9429)
General description
Application
Transporter Function in Caco-2 Cells with Targeted P-Glycoprotein, MRP2 and BCRP Gene Knockout Using Zinc Finger Nucleases
Comparison of Function and Relative Transporter Protein Concentrations in Caco-2 Cells with Single and Double Knockouts of the ABCB1, ABCG2, and ABCC2 Genes
Caco-2 Transporter Knockout Cell Based Assays
Features and Benefits
- A functional double knockout of the BCRP gene and MRP2 gene eliminates the reliance on chemical inhibitors to determine if a compound is an MDR1 substrate
- The vial format enables the BCRP and MRP2 knockout cells to be included in standard drug transporter protocols
- Human assay with no interference from animal inhibitors
- Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality
Legal Information
Disclaimer
Kit Components Also Available Separately
- MTOX1006BCRP/MRP2 Double Knockout Caco-2 Cells, one vial 1 vialSDS
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Articles
We presents an article on The Role of Intestinal Efflux Transporters In Drug Absorption.
Application note on Drug transport assays in a 96-well system using Millicell-96 System from Millipore.
Utilize these Caco-2 cell based assay tools for screening small molecule drug compounds prior to clinical studies and submission to regulatory agencies.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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