MilliporeSigma

CASP9

caspase 9, apoptosis-related cysteine peptidase

Synonyms:
APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56
Species:
UniProtKB ID:
Gene ID:
  • Human(842) Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
  • Mouse(12371) caspase 9
  • Rat(58918) caspase 9, apoptosis-related cysteine peptidase
  • domestic cat(768260) caspase 9, apoptosis-related cysteine peptidase
  • naked mole-rat(101702898) caspase 9, apoptosis-related cysteine peptidase
  • cow(100140945) caspase 9, apoptosis-related cysteine peptidase
  • Horse(100054331) caspase 9, apoptosis-related cysteine peptidase
  • dog(487432) caspase 9, apoptosis-related cysteine peptidase
  • chicken(426970) caspase 9, apoptosis-related cysteine peptidase
  • sheep(101110953) caspase 9, apoptosis-related cysteine peptidase
  • domestic guinea pig(100714954) caspase 9, apoptosis-related cysteine peptidase
  • Zebrafish(492763) caspase 9, apoptosis-related cysteine protease

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-CASP9 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-CASP9 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-CASP9 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
Anti-CASP9 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
Anti-Caspase-9 Antibody, clone 1G22 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Caspase Inhibitor, ≥95% (HPLC),
Species
human
Caspase Inhibitor, ≥95% (HPLC),
Species
human
Caspase Inhibitor, ,
Species
human

Kits

Product Number
Description
Species
Caspase 9 Colorimetric Activity Assay Kit, LEHD, Caspase-9 Colorimetric Activity Assay Kits provide a simple & convenient means for assaying the activity of caspases that recognize the LEHD.,
Species
human
Caspase 9 Colorimetric Activity Assay Kit, LEHD, Caspase-9 Colorimetric Activity Assay Kits provide a simple & convenient means for assaying the activity of caspases that recognize the LEHD.,
Species
human

Proteins

Product Number
Description
Species
Caspase 9 human, ≥90% (SDS-PAGE), recombinant, expressed in E. coli (C-terminal histidine-tagged), buffered aqueous solution, >2,000 units/mg protein,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Casp9,
Species
mouse
MISSION® esiRNA, targeting human CASP9,
Species
human

Small Molecule - Substrate

Product Number
Description
Species
N-Acetyl-Leu-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin, ≥95% (HPLC), powder,
Species
mouse, rat, human