MilliporeSigma

CHRM2

cholinergic receptor, muscarinic 2

Synonyms:
HM2
Species:
UniProtKB ID:
Gene ID:
  • Human(1129) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(243764) cholinergic receptor, muscarinic 2, cardiac
  • Rat(81645) cholinergic receptor, muscarinic 2
  • Domestic Rabbit(100342878) cholinergic receptor, muscarinic 2
  • naked mole-rat(101714286) cholinergic receptor, muscarinic 2
  • chicken(418126) cholinergic receptor, muscarinic 2
  • domestic guinea pig(100715343) cholinergic receptor, muscarinic 2
  • dog(403858) cholinergic receptor, muscarinic 2
  • cow(522170) cholinergic receptor, muscarinic 2
  • domestic cat(101099790) cholinergic receptor, muscarinic 2
  • sheep(101102897) cholinergic receptor, muscarinic 2
  • sheep(100628317) cholinergic receptor, muscarinic 2

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Small Molecule - Agonist

Product Number
Description
Species
Oxotremorine sesquifumarate salt, ≥98% (HPLC), solid,
Species
human
Pilocarpine hydrochloride, ≥99% (titration), powder,
Species
human
Acetyl-β-methylcholine chloride, ≥98% (TLC), powder,
Species
human
Oxotremorine M, solid,
Species
human
Pilocarpine nitrate salt, ≥98% (HPLC),
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Methoctramine hydrate, ≥97% (NMR), solid,
Species
human
Oxybutynin chloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Darifenacin hydrobromide, ≥98% (HPLC),
Species
human
Darifenacin hydrobromide, United States Pharmacopeia (USP) Reference Standard,
Species
human
Oxybutynin chloride, meets EP, USP testing specifications,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Muscarinic Acetylcholine Receptor m2 Antibody, clone M2-2-B3, clone M2-2-B3, Chemicon®, from rat,
Species Reactivity
human, mammals, monkey, rat
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)
Anti-Muscarinic AChR M2 (ACM2) Antibody, clone 3T5W8, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunohistochemistry
western blot
Anti-CHRM2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-Muscarinic Acetylcholine Receptor M2 Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-CHRM2 antibody produced in mouse, clone 4B5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
(+)-Pentazocine, solid,
Species
rat, human
Amitriptyline hydrochloride, ≥98% (TLC), powder,
Species
human
Doxepin hydrochloride, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
Species
human
Haloperidol, powder,
Species
human, rat
Harmaline, ≥95%,
Species
human, rat

Small Molecule - Ligand

Product Number
Description
Species
Aminobenztropine, solid,
Species
human

Proteins

Product Number
Description
Species
ChemiSCREEN Membrane Preparation Recombinant Human M2 Muscarinic Acetylcholine Receptor, Human M2 GPCR membrane prepation for Radioligand binding Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CHRM2,
Species
human