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MAP3K8

mitogen-activated protein kinase kinase kinase 8

Synonyms:
COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT
Species:
UniProtKB ID:
Gene ID:
  • Human(1326) Summary: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
  • Mouse(26410) mitogen-activated protein kinase kinase kinase 8
  • Rat(116596) mitogen-activated protein kinase kinase kinase 8
  • naked mole-rat(101710286) mitogen-activated protein kinase kinase kinase 8
  • cow(535622) mitogen-activated protein kinase kinase kinase 8
  • Zebrafish(563727) mitogen-activated protein kinase kinase kinase 8
  • chicken(420479) mitogen-activated protein kinase kinase kinase 8
  • dog(487085) mitogen-activated protein kinase kinase kinase 8
  • domestic cat(101090624) mitogen-activated protein kinase kinase kinase 8
  • Horse(100063602) mitogen-activated protein kinase kinase kinase 8
  • sheep(101117094) mitogen-activated protein kinase kinase kinase 8
  • Domestic Rabbit(100355566) mitogen-activated protein kinase kinase kinase 8
  • domestic guinea pig(100725834) mitogen-activated protein kinase kinase kinase 8

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-COT antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-phospho-MAP3K8 (pSer400) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
ANTI-COT (MAP3K8/MEKK8)(C-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-MAP3K8 Antibody, clone 1D11 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
affinity binding assay
immunohistochemistry

western blot
Anti-MAP3K8 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot

Cell Lines

Product Number
Description
Species
MCF10A CELLS MAP3K8 P461L, ,
Species
human

Proteins

Product Number
Description
Species
COT (30-397), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
Cot active mouse, recombinant, expressed in baculovirus infected Sf9 cells, ≥50% (SDS-PAGE),
Species
mouse
Cot1 Protein, active, 10 µg, Active, N-terminal 6His-tagged recombinant human Cot1, amino acids 30-397. For use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MAP3K8,
Species
human
MISSION® esiRNA, targeting mouse Map3k8,
Species
mouse