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Sigma-Aldrich

2-Bromo-2-methylpropane

98%

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Synonym(s):
2-methyl-2-bromopropane, tert-Butyl bromide
Linear Formula:
(CH3)3CBr
CAS Number:
Molecular Weight:
137.02
Beilstein:
1730892
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Assay

98%

form

liquid

contains

0.5% potassium carbonate as stabilizer

refractive index

n20/D 1.4279 (lit.)

bp

71-73 °C (lit.)

mp

−20 °C (lit.)

solubility

H2O: insoluble
organic solvents: miscible

density

1.22 g/mL at 20 °C (lit.)

SMILES string

CC(C)(C)Br

InChI

1S/C4H9Br/c1-4(2,3)5/h1-3H3

InChI key

RKSOPLXZQNSWAS-UHFFFAOYSA-N

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1 of 4

This Item
1565826145568.01966
form

liquid

form

liquid

form

-

form

liquid

refractive index

n20/D 1.4279 (lit.)

refractive index

n20/D 1.435 (lit.)

refractive index

-

refractive index

-

bp

71-73 °C (lit.)

bp

90-92 °C (lit.)

bp

72-74 °C (lit.)

bp

-

mp

−20 °C (lit.)

mp

-

mp

-20 °C (lit.)

mp

-20 °C

solubility

H2O: insoluble, organic solvents: miscible

solubility

-

solubility

-

solubility

-

General description

2-Bromo-2-methylpropane (tert-Butyl bromide) is a versatile reactant in organic synthesis, facilitating the introduction of the tert-butyl group. It causes the massive deguanylation of guanine based-nucleosides and massive deadenylation of adenine based-nucleosides.

Application

2-Bromo-2-methylpropane was used to study the massive deadenylation of adenine based-nucleosides induced by halogenated alkanes under physiological conditions.

Pictograms

Flame

Signal Word

Danger

Hazard Statements

Hazard Classifications

Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

60.8 °F - closed cup

Flash Point(C)

16 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Deadenylation of Adenine Based-Nucleosides and Calf thymus DNA Induced by Halogenated Alkanes at the Physiological Condition.
Sherchan J, et al.
Bull. Korean Chem. Soc., 30(10), 2318-2328 (2009)
Deguanylation of guanine based-nucleosides and calf thymus DNA induced by halogenated alkanes at the physiological condition.
Sherchan J and Lee E-S.
Bull. Korean Chem. Soc., 30(12), 2318-2328 (2009)
tert-Butyl Bromide-Promoted Intramolecular Cyclization of 2-Arylamino Phenyl Ketones and Its Combination with Cu-Catalyzed C-N Coupling: Synthesis of Acridines at Room Temperature
Z Cao, et al.
The Journal of Organic Chemistry, 85, 10167-10174 (2020)

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