156671

Potassium tert-butoxide

reagent grade, ≥98%

• Synonym(s): Potassium tert-butylate, Potassium t-butoxide
• Linear Formula: (CH₃)₃COK
• CAS Number: 865-47-4
• Molecular Weight: 112.21
• Beilstein/REAXYS Number: 3556712
• EC Number: 212-740-3
• MDL number: MFCD00012162
• UNSPSC Code: 12352303
• PubChem Substance ID: 24849626
• NACRES: NA.22

Properties

• grade: reagent grade
• Quality Level: 200
• vapor pressure: 1 mmHg ( 220 °C)
• assay: ≥98%
• form: solid
• greener alternative product characteristics: Catalysis; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• mp: 256-258 °C (dec.) (lit.)
• greener alternative category: Aligned,
• SMILES string: [K+].CC(C)(C)[O-]
• InChI: 1S/C4H9O.K/c1-4(2,3)5;/h1-3H3;/q-1;+1
• InChI key: LPNYRYFBWFDTMA-UHFFFAOYSA-N

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for catalytic efficiency. Find details here.

Application

Potassium tert-butoxide has been used as a strong base in the enantioselective synthesis of amines by transfer hydrogenation of N-(tertbutylsulfinyl)imines.
It can also be used:

• To synthesize aliphatic and aromatic amides from corresponding esters and amines.
• As a base in the intramolecular cyclization of aryl ethers, amines, and amides.
• As a catalyst to prepare styrene derivatives from aryl halides and alkenes by Mizoroki-Heck reaction.

Used for greener amidation of esters.

tert-Butoxide-Assisted Amidation of Esters under Green Conditions

Potassium tert-butoxide may be used as a base in the intramolecular cyclization of iodo arene to afford benzopyran via microwave method of synthesis.

Safety Information

• pictograms: GHS02,GHS05
• signalword: Danger
• hcodes: H228,H252,H314
• pcodes: P210 - P235 - P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Sol. 1 - Self-heat. 2 - Skin Corr. 1A
• supp_hazards: EUH014
• Storage Class: 4.2 - Pyrophoric and self-heating hazardous materials
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable