400173

Lithium tert-butoxide

97%

• Synonym(s): LiOtBu
• Linear Formula: (CH₃)₃COLi
• CAS Number: 1907-33-1
• Molecular Weight: 80.05
• UNSPSC Code: 12352300
• NACRES: NA.22
• PubChem Substance ID: 24864902
• EC Number: 217-611-5
• Beilstein/REAXYS Number: 3620018
• MDL number: MFCD00050479
• Assay: 97%
• Form: powder and chunks

Properties

• Quality Segment: 200
• assay: 97%
• form: powder and chunks
• bp: 110 °C/at 0.1333 hPa
• density: 0,897 g/cm³
• SMILES string: [Li+].CC(C)(C)[O-]
• InChI: 1S/C4H9O.Li/c1-4(2,3)5;/h1-3H3;/q-1;+1
• InChI key: LZWQNOHZMQIFBX-UHFFFAOYSA-N

Description

Application

Lithium tert-butoxide (LiOtBu) is a weakly basic and nucleophilic alkali metal oxide commonly used as an initiator for anionic polymerization.
Other synthetic applications:

• In combination with potassium diisopropylamide, LiOtBu can be used to deprotonate 1-(phenylseleno) alkenes and bis (phenylseleno) acetals.
• LiOtBu can mediate the α-alkylation reaction of ketones with primary alcohols in the absence of any transition metal catalyst.
• LiOtBu is an effective base for the synthesis of 3,4,5-trisubstituted 3H-oxazol-2-ones and 3,4-disubstituted (Z)-oxazolidin-2-ones from substituted propargyl alcohols and aryl/alkyl isocyanates using DMF as a solvent.

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H251,H302,H314
• pcodes: P235 - P260 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Self-heat. 1 - Skin Corr. 1B
• supp_hazards: EUH014
• Storage Class: 4.2 - Pyrophoric and self-heating hazardous materials
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges