359270

Sodium tert-butoxide

97%

• Synonym(s): Sodium 2-methylpropan-2-olate, Sodium t-butoxide, Sodium tert-butanolate, Sodium tert-butylate
• Linear Formula: NaOC(CH₃)₃
• CAS Number: 865-48-5
• Molecular Weight: 96.10
• Beilstein/REAXYS Number: 3654215
• EC Number: 212-741-9
• MDL number: MFCD00040575
• UNSPSC Code: 12352107
• PubChem Substance ID: 24862063
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 97%
• SMILES string: [Na+].CC(C)(C)[O-]
• InChI: 1S/C4H9O.Na/c1-4(2,3)5;/h1-3H3;/q-1;+1
• InChI key: MFRIHAYPQRLWNB-UHFFFAOYSA-N

Description

Application

Sodium tert-butoxide may be used as a safe and effective alternative to sodium hydride for the coupling of hydroxyethyl adenine with diethyl p-toluenesulfonyloxymethanephosphonate to form 9-[2-(diethylphosphonomethoxy)ethyl]adenine (diethyl-PMEA), which is a key intermediate to prepare adefovir dipivoxil.
It can also be used:

• To facilitate the coupling of aryl halides with benzene derivatives in the presence of 10-phenanthroline derivative.
• To activate first-row transition-metal pre-catalysts.
• As a base for the amination of aryl chlorides in the presence of a novel palladacyclic precatalyst.

Safety Information

• pictograms: GHS02,GHS05
• signalword: Danger
• hcodes: H228,H251,H314
• pcodes: P210 - P235 - P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Sol. 1 - Self-heat. 1 - Skin Corr. 1B
• supp_hazards: EUH014
• Storage Class: 4.2 - Pyrophoric and self-heating hazardous materials
• wgk_germany: WGK 1
• flash_point_f: 57.2 °F
• flash_point_c: 14 °C
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges