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160601

Sigma-Aldrich

3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine-p,p′-disulfonic acid monosodium salt hydrate

97%

Synonym(s):

FerroZine™ Iron Reagent, PDT disulfonate monosodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C20H13N4NaO6S2 · xH2O
CAS Number:
63451-29-6
Molecular Weight:
492.46 (anhydrous basis)
MDL number:
MFCD00150794
UNSPSC Code:
12352100
PubChem Substance ID:
24849879
NACRES:
NA.21

assay

97%

form

solid

SMILES string

O.[Na+].OS(=O)(=O)c1ccc(cc1)-c2nnc(nc2-c3ccc(cc3)S([O-])(=O)=O)-c4ccccn4

InChI

1S/C20H14N4O6S2.Na.H2O/c25-31(26,27)15-8-4-13(5-9-15)18-19(14-6-10-16(11-7-14)32(28,29)30)23-24-20(22-18)17-3-1-2-12-21-17;;/h1-12H,(H,25,26,27)(H,28,29,30);;1H2/q;+1;/p-1

InChI key

MBOKSYFCYXIJRZ-UHFFFAOYSA-M

Application

3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine-p,p′-disulfonic acid monosodium salt hydrate has been used as a colorimetric indicator for ferroxidase assay.
Reagent for the determination of Fe and Co, and Ag, Cu, and Ni.

Legal Information

FerroZine is a trademark of Hach Company

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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G Al-Jabari et al.
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Silver(I), copper(II) and nickel(II) can be reduced to the metallic state by formaldehyde at pH 11, chromium(II) in 2.5M sulphuric acid, and borohydride at pH 5.5-6.0, respectively. Reoxidation of these metals with iron(III) in the presence of Ferrozine enables their
Expression of iron-related proteins at the neurovascular unit supports reduction and reoxidation of iron for transport through the blood-brain barrier.
Burkhart A, et al.
Molecular Neurobiology, 53(10), 7237-7253 null
Chandrika N Deshpande et al.
PloS one, 12(9), e0184366-e0184366 (2017-09-08)
Hephaestin is a large membrane-anchored multicopper ferroxidase involved in mammalian iron metabolism. Newly absorbed dietary iron is exported across the enterocyte basolateral membrane by the ferrous iron transporter ferroportin, but hephaestin increases the efficiency of this process by oxidizing the
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