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160601

Sigma-Aldrich

3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine-p,p′-disulfonic acid monosodium salt hydrate

97%

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Synonym(s):
FerroZine Iron Reagent, PDT disulfonate monosodium salt hydrate
Empirical Formula (Hill Notation):
C20H13N4NaO6S2 · xH2O
CAS Number:
Molecular Weight:
492.46 (anhydrous basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.21

assay

97%

form

solid

SMILES string

O.[Na+].OS(=O)(=O)c1ccc(cc1)-c2nnc(nc2-c3ccc(cc3)S([O-])(=O)=O)-c4ccccn4

InChI

1S/C20H14N4O6S2.Na.H2O/c25-31(26,27)15-8-4-13(5-9-15)18-19(14-6-10-16(11-7-14)32(28,29)30)23-24-20(22-18)17-3-1-2-12-21-17;;/h1-12H,(H,25,26,27)(H,28,29,30);;1H2/q;+1;/p-1

InChI key

MBOKSYFCYXIJRZ-UHFFFAOYSA-M

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This Item
P9762178268P5338
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

assay

97%

assay

-

assay

≥97.5% (HPLC)

assay

-

Application

3-(2-Pyridyl)-5,6-diphenyl-1,2,4-triazine-p,p′-disulfonic acid monosodium salt hydrate has been used as a colorimetric indicator for ferroxidase assay.
Reagent for the determination of Fe and Co, and Ag, Cu, and Ni.

Legal Information

FerroZine is a trademark of Hach Company

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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G Al-Jabari et al.
Talanta, 34(5), 479-482 (1987-05-01)
Silver(I), copper(II) and nickel(II) can be reduced to the metallic state by formaldehyde at pH 11, chromium(II) in 2.5M sulphuric acid, and borohydride at pH 5.5-6.0, respectively. Reoxidation of these metals with iron(III) in the presence of Ferrozine enables their
Expression of iron-related proteins at the neurovascular unit supports reduction and reoxidation of iron for transport through the blood-brain barrier.
Burkhart A, et al.
Molecular Neurobiology, 53(10), 7237-7253 null
Chandrika N Deshpande et al.
PloS one, 12(9), e0184366-e0184366 (2017-09-08)
Hephaestin is a large membrane-anchored multicopper ferroxidase involved in mammalian iron metabolism. Newly absorbed dietary iron is exported across the enterocyte basolateral membrane by the ferrous iron transporter ferroportin, but hephaestin increases the efficiency of this process by oxidizing the
Danuta Zielinska et al.
Nutrients, 11(5) (2019-05-28)
Plant-derived food consumption has gained attention as potential intervention for the improvement of intestinal inflammatory diseases. Apple consumption has been shown to be effective at ameliorating intestinal inflammation symptoms. These beneficial effects have been related to (poly)phenols, including phloretin (Phlor)
Pao-Yuan Hsiao et al.
Scientific reports, 7(1), 9175-9175 (2017-08-25)
Plant defensins (PDFs) are cysteine-rich peptides that have a range of biological functions, including defence against fungal pathogens. However, little is known about their role in defence against bacteria. In this study, we showed that the protein encoded by ARABIDOPSIS

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