211222
Boron tribromide solution
1.0 M in methylene chloride
Synonym(s):
Tribromoboron
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About This Item
Empirical Formula (Hill Notation):
BBr3
CAS Number:
Molecular Weight:
250.52
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
Form:
liquid
form
liquid
Quality Segment
concentration
1.0 M in methylene chloride
density
1.467 g/mL at 25 °C
SMILES string
BrB(Br)Br
InChI
1S/BBr3/c2-1(3)4
InChI key
ILAHWRKJUDSMFH-UHFFFAOYSA-N
General description
Boron tribromide (BBr3) is a commonly used reagent in organic chemistry for demethylation.
Application
Reactant for preparation of:
- Drug intermediate 6-nitro-L-DOPA
- Luminescent polystyrene derivatives with sterically protected carbazolylborane moieties
- High-quality boron-doped graphene via Wurtz-type reductive coupling reaction
- Mercapto-(+)-methamphetamine haptens for synthesis of (+)-methamphetamine conjugate vaccines with improved epitope densities
- Micrometer-sized organic molecule-DNA hybrid structures
- Borane complexes via electrophilic aromatic borylation reactions
- A 5-HT2C receptor agonist
- Biphenyl-derivatives possessing tertiary amino groups as β-secretase(BACE1) inhibitors for the treatment of Alzheimer′s disease
- A highly near-IR region fluorescent p-extended boron aza-dipyrromethene moiety unit
- Tetrahydroisoquinoline derivatives via intramolecular cyclization of methoxy-substituted N-phenethylimides
Used to cleave aryl methyl ethers in a synthesis of a benzopyranobenzopyran from a coumarin scaffold.
Packaging
The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.
Legal Information
Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
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Danger
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Skin Corr. 1A - STOT SE 3
target_organs
Central nervous system
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Azobenzene derivatives show anti-cancer activity against pancreatic cancer cells only under nutrient starvation conditions via G0/G1 cell cycle arrest
Shinzawa K, et al.
Tetrahedron, 85, 132077-132077 (2021)
Tetrahedron Letters, 47, 5909-5909 (2006)
Andrey S Mereshchenko et al.
Nature chemistry, 7(7), 562-568 (2015-06-24)
'Roaming' is a new and unusual class of reaction mechanism that has recently been discovered in unimolecular dissociation reactions of isolated molecules in the gas phase. It is characterized by frustrated bond cleavage, after which the two incipient fragments 'roam'
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 211222-4X25ML | 04061838771650 |
| 211222-10ML | 04061838125514 |
| 211222-100ML | 04061838771643 |
| 211222-2L | 04061838125521 |
| 211222-800ML | 04061838771667 |