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236314

Sigma-Aldrich

p-Toluidine

99.6%

Synonym(s):

4-Aminotoluene, 4-Methylaniline

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About This Item

Linear Formula:
CH3C6H4NH2
CAS Number:
106-49-0
Molecular Weight:
107.15
Beilstein/REAXYS Number:
471281
EC Number:
203-403-1
MDL number:
MFCD00007906
UNSPSC Code:
12352100
PubChem Substance ID:
24854162
NACRES:
NA.22
assay:
99.6%
bp:
200 °C (lit.)
vapor pressure:
0.26 mmHg ( 25 °C)
0.66 mmHg ( 38 °C)
Pricing and availability is not currently available.

vapor density

3.9 (vs air)

vapor pressure

0.26 mmHg ( 25 °C)
0.66 mmHg ( 38 °C)

assay

99.6%

form

crystalline

autoignition temp.

899 °F

expl. lim.

6.6 %

pH

7.8 (7 g/L)

bp

200 °C (lit.)

mp

41-46 °C (lit.)

solubility

water: soluble 135 part(lit.)
acetone: freely soluble(lit.)
alcohol: freely soluble(lit.)
carbon disulfide: freely soluble(lit.)
diethyl ether: freely soluble(lit.)
methanol: freely soluble(lit.)
oil: freely soluble(lit.)

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General description

p-Toluidine undergoes oxidative coupling reaction with catecholamine to form an orange water-soluble dye during flow injection-spectrophotometric determination of catecholamine drugs[1].

Application

p-Toluidine has been used in preparation of:
  • aromatic azo compounds[2]
  • bidentate Schiff base ligands via condensation with salicylaldehyde[3]

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Skin Sens. 1A

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM8077
BCCM0715
BCCM2400
BCCK4226
BCCH4698

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Flow injection-spectrophotometeric determination of some catecholamine drugs in pharmaceutical preparations via oxidative coupling reaction with< i> p</i>-toluidine and sodium periodate.
Abdulrahman LK, et al.
Analytica Chimica Acta, 538(1), 331-335 (2005)
Ruthenium (II) complexes containing bidentate Schiff bases and their antifungal activity.
Dharmaraj N, et al.
Transition Met. Chem. (London), 26(1-2), 105-109 (2001)
Paul G Stevenson et al.
Journal of chromatography. A, 1218(45), 8255-8263 (2011-10-11)
Several simple techniques are presented for the identification of the boundaries of chromatographic peaks. These methods provide a significant reduction in the time needed to perform the rapid, automatic calculation of the central peak moments and to evaluate the quality
Shunji Ito et al.
The Journal of organic chemistry, 70(6), 2285-2293 (2005-03-12)
[reaction: see text] N,N-Di(6-azulenyl)-p-toluidine (1a) and N,N,N',N'-tetra(6-azulenyl)-p-phenylenediamine (2a) and their derivatives with 1,3-bis(ethoxycarbonyl) substituents on each 6-azulenyl group (1b and 2b) were prepared by Pd-catalyzed amine azulenylation and characterized as a study into new aromatic amines for multistage amphoteric redox
J C Kennelly et al.
Mutation research, 137(1), 39-45 (1984-07-01)
The conventional Ames assay metabolising system was confirmed to be deficient in its ability to N-acetylate. This may render the test less sensitive to compounds which normally have an acetylation step during their in vivo activation to carcinogens. The addition
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