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242284

Sigma-Aldrich

Aniline

ACS reagent, ≥99.5%

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Synonym(s):
Aminobenzene, Benzenamine
Linear Formula:
C6H5NH2
CAS Number:
Molecular Weight:
93.13
Beilstein:
605631
EC Number:
MDL number:
eCl@ss:
39030407
PubChem Substance ID:
NACRES:
NA.21

grade

ACS reagent

Quality Level

vapor density

3.22 (185 °C, vs air)

vapor pressure

0.7 mmHg ( 25 °C)

Assay

≥99.5%

form

liquid

autoignition temp.

1139 °F

expl. lim.

11 %

impurities

Hydrocarbons, passes test
Nitrobenzene, passes test (lim. ~0.001%)
≤0.01% chlorobenzene

ign. residue

≤0.005%

refractive index

n20/D 1.586 (lit.)

bp

184 °C (lit.)

mp

−6 °C (lit.)

solubility

water: soluble

density

1.022 g/mL at 25 °C (lit.)

SMILES string

Nc1ccccc1

InChI

1S/C6H7N/c7-6-4-2-1-3-5-6/h1-5H,7H2

InChI key

PAYRUJLWNCNPSJ-UHFFFAOYSA-N

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1 of 4

This Item
132934488100676810
Aniline ACS reagent, ≥99.5%

Sigma-Aldrich

242284

Aniline

-
Aniline ReagentPlus®, 99%

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132934

Aniline

-
Aniline-15N 98 atom % 15N

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488100

Aniline-15N

-
Ethyl acetate ACS reagent, ≥99.5%

Sigma-Aldrich

676810

Ethyl acetate

Essential Grade
vapor density

3.22 (185 °C, vs air)

vapor density

3.22 (185 °C, vs air)

vapor density

-

vapor density

3 (20 °C, vs air)

vapor pressure

0.7 mmHg ( 25 °C)

vapor pressure

0.7 mmHg ( 25 °C)

vapor pressure

-

vapor pressure

73 mmHg ( 20 °C)

assay

≥99.5%

assay

99%

assay

99% (CP)

assay

≥99.5%

form

liquid

form

liquid

form

-

form

liquid

autoignition temp.

1139 °F

autoignition temp.

1139 °F

autoignition temp.

-

autoignition temp.

801 °F

Application

Aniline is an aromatic primary amine that may be used as a reactant in the synthesis of organic intermediates such as 3-chloro-N-phenyl-pyridin-2-amine, (Z)-methyl 3-(phenylamino)but-2-enoate, 2-iodo-N-phenylbenzamide, 2,4-dichloroquinoline and N-(2-propynyl)aniline.

Biochem/physiol Actions

The acute toxicity of aniline involves its activation in vivo to 4-hydroxyaniline and the formation of adducts with hemoglobin. In erythrocytes, this is associated with the release of iron and the accumulation of methemoglobin and the development of hemolytic anemia and inflammation of the spleen. Tumor formation is often observed in the spleen on prolonged administration.

Physical properties

Material darkens in storage to reddish-brown with no loss in purity.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Muta. 2 - Skin Sens. 1 - STOT RE 1

Target Organs

Blood

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

158.0 °F - closed cup

Flash Point(C)

70 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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