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244929

Sigma-Aldrich

Dichloro(ethylenediamine)platinum(II)

99%

Synonym(s):

Dichloro(1,2-diaminoethane)platinum, Dichloro(1,2-ethanediamine)platinum, Platinum ethylenediamine dichloride

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About This Item

Linear Formula:
(H2NCH2CH2NH2)PtCl2
CAS Number:
14096-51-6
Molecular Weight:
326.08
EC Number:
237-943-4
MDL number:
MFCD00000011
UNSPSC Code:
12161600
PubChem Substance ID:
24854717
NACRES:
NA.22

assay

99%

form

solid

reaction suitability

core: platinum
reagent type: catalyst

SMILES string

Cl[Pt]Cl.NCCN

InChI

1S/C2H8N2.2ClH.Pt/c3-1-2-4;;;/h1-4H2;2*1H;/q;;;+2/p-2

InChI key

LMABILRJNNFCPG-UHFFFAOYSA-L

Related Categories

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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B E Bowler et al.
Biochemistry, 25(10), 3031-3038 (1986-05-20)
We report the DNA binding site preferences of the novel molecule AO-Pt, in which the anticancer drug dichloro(ethylenediamine)platinum(II) is linked by a hexamethylene chain to acridine orange. The sequence specificity of platinum binding was mapped by exonuclease III digestion of
T J Kelley et al.
Cancer biochemistry biophysics, 13(3), 135-146 (1993-06-01)
Cisplatin (cis-diamminedichloroplatinum(II); cis-DDP) is used as an effective drug for treatment of a variety of cancers, such as carcinomas of bladder, ovarian, and testicular origin. Immunopurified DNA polymerase-alpha from rat prostate tumor PA-3 cells was inhibited (50%) in the presence
W L Armarego et al.
European journal of biochemistry, 164(2), 403-409 (1987-04-15)
Potassium tetrachloroplatinate (K2PtCl4) inactivates dihydropteridine reductase from human brain in a time-dependent and irreversible manner. The inactivation has been followed by measuring enzyme activity and fluorescence changes. The enzyme is completely protected from inactivation by NADH, the pterin cofactor [quinonoid
E Kimura et al.
Cancer chemotherapy and pharmacology, 32(6), 419-424 (1993-01-01)
Expression of the heat-shock protein HSP-60 is associated with poor survival in patients with ovarian carcinoma. We examined both the nature of the interaction between hyperthermia and cisplatin (DDP) using the human ovarian carcinoma cell line 2008 and the effect
A P Jekunen et al.
Cancer research, 54(10), 2680-2687 (1994-05-15)
The cellular pharmacology of the tritium-labeled cisplatin analogue dichloro(ethylenediamine)platinum(II) ([3H]DEP) was compared in cisplatin-sensitive 2008 and resistant 2008/C13*5.25 human ovarian carcinoma cells. The cellular content of total [3H], ultrafiltrable [3H], and free native [3H]DEP was measured during and following incubation
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