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244929

Sigma-Aldrich

Dichloro(ethylenediamine)platinum(II)

99%

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Synonym(s):
Dichloro(1,2-diaminoethane)platinum, Dichloro(1,2-ethanediamine)platinum, Platinum ethylenediamine dichloride
Linear Formula:
(H2NCH2CH2NH2)PtCl2
CAS Number:
Molecular Weight:
326.08
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

assay

99%

form

solid

reaction suitability

core: platinum
reagent type: catalyst

SMILES string

Cl[Pt]Cl.NCCN

InChI

1S/C2H8N2.2ClH.Pt/c3-1-2-4;;;/h1-4H2;2*1H;/q;;;+2/p-2

InChI key

LMABILRJNNFCPG-UHFFFAOYSA-L

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This Item
244937401609404322
assay

99%

assay

-

assay

96%

assay

-

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

reaction suitability

core: platinum, reagent type: catalyst

reaction suitability

core: platinum, reagent type: catalyst

reaction suitability

core: platinum, reagent type: catalyst

reaction suitability

core: platinum, reagent type: catalyst

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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S Isonishi et al.
British journal of cancer, 69(2), 217-221 (1994-02-01)
Sensitivity to platinum-containing drugs is believed to be a function of how much drug enters the cell, the extent of DNA adduct formation and the rate at which DNA is repaired. Activation of protein kinase C by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was
R J Holmes et al.
Journal of inorganic biochemistry, 85(2-3), 209-217 (2001-06-19)
A series of intercalator-tethered platinum(II) complexes PtLCl(2) have been prepared where L are the diamine ligands N-[2-[(aminoethyl)amino]ethyl]-9-aminoacridine-4-carboxamide, N-[3-[(2-aminoethyl)amino]propyl]-9-aminoacridine-4-carboxamide, N-[4-[(2-aminoethyl)amino]butyl]-9-aminoacridine-4-carboxamide and N-[5-[(aminoethyl)amino]pentyl]-9-aminoacridine-4-carboxamide and N-[6-[(aminoethyl)amino]hexyl]-9-aminoacridine-4-carboxamide. The activity of the complexes was assessed in the CH-1, CH-1cisR, 41M, 41McisR and SKOV-3 cell lines.
P Naredi et al.
The Journal of clinical investigation, 95(3), 1193-1198 (1995-03-01)
Cross-resistance between cisplatin (DDP) and metalloid salts in human cells was sought on the basis that mechanisms that mediate metalloid salt cross-resistance in prokaryotes are evolutionarily conserved. Two ovarian and two head and neck carcinoma cell lines selected for DDP
L C Perrin et al.
Anti-cancer drug design, 14(3), 243-252 (1999-09-29)
An in vitro transcription assay was used to probe the sequence specificity of the binding of phenazine-tethered platinum complexes to DNA. It was found that when compared to cis-dichloro(ethylenediamine)platinum(II), the number of RNA polymerase blockage sites was increased by approximately
Akihiko Yoshikawa et al.
Journal of the American Society for Mass Spectrometry, 20(6), 1015-1029 (2009-03-17)
Dichloro(ethylenediamine)platinum(II), Pt(en)Cl(2), was dissolved in H(2)O and D(2)O, and the resulting aqueous solutions were electrosprayed into a quadrupole ion-trap mass spectrometer. A series of major and minor ionic hydrolysis products were detected. These ions were then subjected to collision-induced dissociation.

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