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282227

Sigma-Aldrich

Chlorhexidine

≥99.5%

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Synonym(s):
1,1′-Hexamethylenebis[5-(4-chlorophenyl)biguanide]
Linear Formula:
[-(CH2)3NHC(=NH)NHC(=NH)NHC6H4Cl]2
CAS Number:
Molecular Weight:
505.45
Beilstein/REAXYS Number:
2826432
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

≥99.5%

form

powder

impurities

<1.0% water

mp

134-136 °C (lit.)

solubility

water: soluble 0.08% at 20 °C

SMILES string

Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

InChI

1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)

InChI key

GHXZTYHSJHQHIJ-UHFFFAOYSA-N

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1 of 4

This Item
PHR1421C9394C6143
vibrant-m

282227

Chlorhexidine

vibrant-m

PHR1421

Chlorhexidine

vibrant-m

C9394

Chlorhexidine digluconate solution

solubility

water: soluble 0.08% at 20 °C

solubility

-

solubility

water: soluble 50 % (w/v)

solubility

ethanol: 50 mg/mL

Quality Level

100

Quality Level

300

Quality Level

200

Quality Level

200

form

powder

form

-

form

liquid

form

powder

mp

134-136 °C (lit.)

mp

134-136 °C (lit.)

mp

-

mp

-

impurities

<1.0% water

impurities

-

impurities

-

impurities

-

General description

Effect of the chlorhexidine:hydroxypropyl-β-cyclodextrin inclusion compound on in vitro slabs of bovine dentine has been investigated.

Chlorhexidine is a cationic surfactant with broad-spectrum antimicrobial activity. It is used as a disinfectant in periodontal therapy and surgical scrubs.

Application

Chlorhexidine, the "gold standard" in oral antiseptics, has been used to optimize novel slow release chlorhexidine coatings based on fatty acids in surgical sutures. Chlorhexidine, antibacterial agent, has been used in preparaing chlorhexidine-functionalized calcium phosphate nanoparticles, useful for oral hygiene and dental treatment.

pictograms

CorrosionEnvironment

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Carolina Ferreira Franco et al.
Artificial organs, 27(5), 486-491 (2003-05-20)
The aim of this work was study the effect of the chlorhexidine : hydroxypropyl-beta-cyclodextrin (CLX : HP-beta-CD) inclusion compound (IC) on in vitro slabs of bovine dentine. The substantivity, antimicrobial activity, and morphological effect of this inclusion compound were evaluated.
Chlorhexidine-loaded calcium phosphate nanoparticles for dental maintenance treatment: combination of mineralising and antibacterial effects.
Kovtun A, et al.
Royal Society of Chemistry Advances, 2(3), 870-875 (2012)
Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review
Van Strydonck DA, et al.
Journal of Clinical Periodontology, 39, 1042-1055 (2012)
Matthias Maiwald et al.
PloS one, 7(9), e44277-e44277 (2012-09-18)
Skin antisepsis is a simple and effective measure to prevent infections. The efficacy of chlorhexidine is actively discussed in the literature on skin antisepsis. However, study outcomes due to chlorhexidine-alcohol combinations are often attributed to chlorhexidine alone. Thus, we sought
Hiroshi Kinashi et al.
Journal of the American Society of Nephrology : JASN, 24(10), 1627-1642 (2013-08-31)
Peritoneal fibrosis (PF) causes ultrafiltration failure (UFF) and is a complicating factor in long-term peritoneal dialysis. Lymphatic reabsorption also may contribute to UFF, but little is known about lymphangiogenesis in patients with UFF and peritonitis. We studied the role of

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