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328022

Sigma-Aldrich

4-Methylhippuric acid

98%

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Synonym(s):
N-(4-Methylbenzoyl)glycine, p-Toluric acid
Linear Formula:
CH3C6H4CONHCH2CO2H
CAS Number:
Molecular Weight:
193.20
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

form

powder

mp

163-165 °C (lit.)

SMILES string

Cc1ccc(cc1)C(=O)NCC(O)=O

InChI

1S/C10H11NO3/c1-7-2-4-8(5-3-7)10(14)11-6-9(12)13/h2-5H,6H2,1H3,(H,11,14)(H,12,13)

InChI key

NRSCPTLHWVWLLH-UHFFFAOYSA-N

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1 of 4

This Item
270792B12407328014
4-Methylhippuric acid 98%

328022

4-Methylhippuric acid

4-(Chloromethyl)benzoic acid 95%

270792

4-(Chloromethyl)benzoic acid

4-Benzoylbenzoic acid 99%

B12407

4-Benzoylbenzoic acid

3-Methylhippuric acid 98%

328014

3-Methylhippuric acid

form

powder

form

powder

form

crystals

form

-

mp

163-165 °C (lit.)

mp

201-202 °C (lit.)

mp

198-200 °C (lit.)

mp

138-140 °C (lit.)

General description

4-Methylhippuric acid is the major metabolite of xylene and has been determined in urine by gas chromatography.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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P T Mayer et al.
AAPS pharmSci, 2(2), E14-E14 (2001-12-14)
To explore the independence of functional group contributions to permeability of nonelectrolytes across egg lecithin bilayers, the transport rates were measured of a series of alpha-substituted p-methylhippuric acids (-H, -Cl, -OCH3, -CN, -OH, -COOH, and -CONH2) across egg lecithin lipid
Peter T Mayer et al.
Journal of pharmaceutical sciences, 91(3), 640-646 (2002-03-29)
The barrier domain solubility-diffusion theory of lipid bilayer permeability relates the permeability coefficient (P(m)) to the solute's partition coefficient (PC(barrier/w)) and diffusion coefficient (D(barrier)) in the ordered chain region of the bilayer that serves as the barrier region for polar
Measurement of exposure to xylenes by separate determination of m- and p-methylhippuric acids in urine.
M Morin et al.
Journal of chromatography, 210(2), 346-349 (1981-06-05)
G Bieniek et al.
British journal of industrial medicine, 38(3), 304-306 (1981-08-01)
The separation of hippuric and m-methylhippuric acid as toluene and m-xylene metabolites present in urine of people exposed simultaneously to toluene and xylene is described. Chloroform was used for hippuric and m-methylhippuric acid extraction. Satisfactory separation of these metabolites was
O Inoue et al.
International archives of occupational and environmental health, 64(7), 533-539 (1993-01-01)
The correlation between exposure to three xylene isomers and resulting urinary excretion of corresponding methylhippuric acid (MHA) isomers was studied among 175 Chinese workers of both sexes who had been predominantly exposed to xylenes (exposure to xylenes accounting for 70%

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