MilliporeSigma
All Photos(1)

Documents

365645

Sigma-Aldrich

Andrographolide

98%

Sign Into View Organizational & Contract Pricing

Synonym(s):
3-dehydroandrographolide, Andrographis, Andrographiside aglycon
Empirical Formula (Hill Notation):
C20H30O5
CAS Number:
Molecular Weight:
350.45
Beilstein/REAXYS Number:
42762
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

form

powder

optical activity

[α]20/D −126°, c = 1.5 in acetic acid

mp

229-232 °C (lit.)

SMILES string

C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](C\C=C3/[C@H](O)COC3=O)C(=C)CC[C@H]12

InChI

1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

InChI key

BOJKULTULYSRAS-OTESTREVSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
G104690281PHL89561
Andrographolide 98%

365645

Andrographolide

[6]-Gingerol ≥98% (HPLC)

G1046

[6]-Gingerol

Andrographolide analytical standard

90281

Andrographolide

Andrographolide phyproof® Reference Substance

PHL89561

Andrographolide

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

-

form

powder

form

-

form

-

form

solid

mp

229-232 °C (lit.)

mp

-

mp

-

mp

-

optical activity

[α]20/D −126°, c = 1.5 in acetic acid

optical activity

-

optical activity

-

optical activity

-

General description

Andrographolide, a bioactive diterpene lactone, is the main constituent of Andrographis paniculata, a plant used in traditional medicines. It is known to have different biological activities such as anti-inflammatory, anti-malarial, anti-cancer and hepatoprotective activity. It also shows potent anti-viral effect against dengue virus.

Biochem/physiol Actions

Diterpenoid lactone with anti-inflammatory properties. It blocks T-cell proliferation to allogenic stimuli and the chemotactic migration of macrophages induced by complement. Blocks the proliferation of several cancer cell lines in vitro.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 5

1 of 5

Neoandrographolide phyproof® Reference Substance

PHL89740

Neoandrographolide

3-Carene ≥90%

Sigma-Aldrich

W382108

3-Carene

Daltroban >98% (HPLC)

Sigma-Aldrich

D7441

Daltroban

(−)-α-Thujone ≥96.0% (GC)

Sigma-Aldrich

89231

(−)-α-Thujone

Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata.
Rajagopal S, et al.
Journal of Experimental Therapeutics & Oncology, 3(3), 147-158 (2003)
In vitro and in vivo anti-inflammatory effects of andrographolide.
Abu-Ghefreh Ala'AA, et al.
International Immunopharmacology, 9(3), 313-318 (2009)
Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride.
Handa SS and Sharma A.
The Indian Journal of Medical Research, 92, 276-283 (1990)
Activity of andrographolide against dengue virus.
Panraksa P, et al.
Antiviral Research, 139, 69-78 (2017)
Jonathan Chee Woei Lim et al.
Clinical and experimental pharmacology & physiology, 39(3), 300-310 (2011-10-25)
1. Andrographis paniculata (Burm. f) Nees, commonly known as 'king of bitters', is a herbaceous plant belonging to the Family Acanthaceae. It has been widely used for centuries in Asian countries like China, India, Thailand and Malaysia for the treatment of

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service