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Poly(ethylene glycol) methacrylate

average Mn 360, contains 500-800 ppm MEHQ as inhibitor

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Synonym(s):
Ethoxylated 2-hydroxyethyl methacrylate, PEGMA, Poly(ethylene oxide) monomethacrylate
Linear Formula:
H2C=C(CH3)CO(OCH2CH2)nOH
CAS Number:
MDL number:
NACRES:
NA.23

form

liquid

Quality Level

mol wt

average Mn 360

contains

500-800 ppm MEHQ as inhibitor

reaction suitability

reagent type: cross-linking reagent
reaction type: Polymerization Reactions

refractive index

n20/D 1.464

density

1.105 g/mL at 25 °C

Ω-end

hydroxyl

α-end

methacrylate

polymer architecture

shape: linear
functionality: heterobifunctional

InChI

1S/C6H10O3/c1-5(2)6(8)9-4-3-7/h7H,1,3-4H2,2H3

InChI key

WOBHKFSMXKNTIM-UHFFFAOYSA-N

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This Item
447935409529447943
mol wt

average Mn 360

mol wt

average Mn 300

mol wt

average Mn 500

mol wt

average Mn 500

reaction suitability

reagent type: cross-linking reagent
reaction type: Polymerization Reactions

reaction suitability

reagent type: chemical modification reagent
reaction type: Polymerization Reactions

reaction suitability

reagent type: cross-linking reagent
reaction type: Polymerization Reactions

reaction suitability

reagent type: chemical modification reagent
reaction type: Polymerization Reactions

density

1.105 g/mL at 25 °C

density

1.05 g/mL at 25 °C

density

1.101 g/mL at 25 °C

density

1.08 g/mL at 25 °C

Ω-end

hydroxyl

Ω-end

methacrylate

Ω-end

hydroxyl

Ω-end

methacrylate

α-end

methacrylate

α-end

methoxy

α-end

methacrylate

α-end

methoxy

General description

Polyethylene glycol (PEG) is a suitable material for biological applications since it does not trigger an immune response. It can by synthesized by anionic ring opening polymerization of ethylene oxide with a range of end groups (such as methacrylate: PEGMA) attached. PEG is a hydrophilic polymer that can form hydrogels when cross linked into networks. Acrylate and methacrylate chain ends undergo chain polymerization to from PEGMA hydrogels.

Application

PEGMA can beused as a monomer to synthesize:
  • Degradable microspheres using asuspension polymerization process. The amphiphilic nature of PEGMA allows performingthe polymerization by direct oil in the water suspension process.
  • Polymeric chelating beads for the effectiveremoval of heavy metals from aqueous solutions.
It can also be used to synthesize micro or nanoparticles-basedchitosan /PEGMA composite by Michael addition reaction. The PEGMA graftingimproves the solubility of chitosan in aqueous media. These particles can beused as carriers in the ophthalmic drug delivery system.

Physical form

Monomethacrylate functionalized

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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25G
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Mir Mukkaram Ali;
Macromolecules, 37, 5219-5227 (2004)
Biofouling-resistance expanded poly (tetrafluoroethylene) membrane with a hydrogel-like layer of surface-immobilized poly (ethylene glycol) methacrylate for human plasma protein repulsions.
Chang Y, et al.
Journal of Membrane Science, 323(1), 77-84 (2008)

Articles

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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