498270

1-Chloro-N,N,2-trimethyl-1-propenylamine

96%

• Synonym(s): Ghosez′s reagent
• Linear Formula: (CH₃)₂C=C(Cl)N(CH₃)₂
• CAS Number: 26189-59-3
• Molecular Weight: 133.62
• NACRES: NA.22
• PubChem Substance ID: 24873186
• UNSPSC Code: 12352302
• MDL number: MFCD00800562
• Assay: 96%

Properties

• Quality Level: 100
• assay: 96%
• refractive index: n20/D 1.453 (lit.)
• bp: 129-130 °C (lit.)
• density: 1.01 g/mL at 25 °C (lit.)
• functional group: amine, chloro
• storage temp.: 2-8°C
• SMILES string: CN(C)\C(Cl)=C(\C)C
• InChI: 1S/C6H12ClN/c1-5(2)6(7)8(3)4/h1-4H3
• InChI key: GQIRIWDEZSKOCN-UHFFFAOYSA-N

Description

Application

1-Chloro-N,N,2-trimethyl-1-propenylamine is an acid halogenation reagent developed by Ghosez, that enables the conversion of carboxylic acids into the corresponding chlorides under strictly neutral conditions. This method was successfully used in the total synthesis of caloporoside, roseophilin, (-)-enniatin B, (±)-epimeloscine and (±)-meloscine.

Safety Information

• pictograms: GHS02,GHS05
• signalword: Danger
• pcodes: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Storage Class: 3 - Flammable liquids
• wgk: WGK 3
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
• hcodes: H225,H314
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
• flash_point_f: <73.4 °F - closed cup
• flash_point_c: < 23 °C - closed cup