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518522

Sigma-Aldrich

1-Piperidinecarbonyl chloride

97%

Synonym(s):

N-Chloroformylpiperidine, NSC 50227

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About This Item

Empirical Formula (Hill Notation):
C6H10ClNO
CAS Number:
13939-69-0
Molecular Weight:
147.60
MDL number:
MFCD00973554
UNSPSC Code:
12352100
PubChem Substance ID:
24874029
NACRES:
NA.22

assay

97%

refractive index

n20/D 1.459 (lit.)

bp

242 °C (lit.)

density

1.18 g/mL at 25 °C (lit.)

SMILES string

ClC(=O)N1CCCCC1

InChI

1S/C6H10ClNO/c7-6(9)8-4-2-1-3-5-8/h1-5H2

InChI key

BIFDXOOJPDHKJH-UHFFFAOYSA-N

Application

Reactant for synthesis of:
A coumarin-based HIV-1 Vpr inhibitor
Antitumor agents as potent chemosensitizers
Oxime carbamates as reversible inhibitors of fatty acid amide hydrolase
Dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes
Bisarylmaleimide glycogen synthase kinase-3 inhibitors
Lysosomal acid lipase inhibitors and potential Niemann-Pick type C disease therapeutics

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Correlation of the rates of solvolysis of 1-piperidincarbonyl chloride using the extended Grunwald-Winstein equation.
Choi H, et al.
Bull. Korean Chem. Soc., 32(11), 3941-3941 (2011)
Self-assembling decacyclene triimides prepared through a regioselective hextuple Friedel-Crafts carbamylation.
Toan V Pho et al.
Angewandte Chemie (International ed. in English), 52(5), 1446-1451 (2012-12-21)
Jure Borišek et al.
Journal of medicinal chemistry, 58(17), 6928-6937 (2015-08-19)
Cathepsin K is a major drug target for osteoporosis and related-bone disorders. Using a combination of virtual combinatorial chemistry, QSAR modeling, and molecular docking studies, a series of cathepsin K inhibitors based on N-(functionalized benzoyl)-homocycloleucyl-glycinonitrile scaffold was developed. In order
New nordihydroguaiaretic acid derivatives as anti-HIV agents.
Hwu JR, et al.
Bioorganic & Medicinal Chemistry Letters, 18(6), 1884-1888 (2008)

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