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Sigma-Aldrich

4-Morpholinecarbonyl chloride

98%

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Empirical Formula (Hill Notation):
C5H8ClNO2
CAS Number:
Molecular Weight:
149.58
Beilstein/REAXYS Number:
116257
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

98%

form

liquid

refractive index

n20/D 1.498 (lit.)

bp

137-138 °C/33 mmHg (lit.)

density

1.282 g/mL at 25 °C (lit.)

SMILES string

ClC(=O)N1CCOCC1

InChI

1S/C5H8ClNO2/c6-5(8)7-1-3-9-4-2-7/h1-4H2

InChI key

XMWFMEYDRNJSOO-UHFFFAOYSA-N

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General description

4-Morpholinecarbonyl chloride is a photographic intermediate. Rates of solvolysis of 4-morpholinecarbonyl chloride with N-alkyl group in aqueous binary solvents of acetone, ethanol, methanol, methanol-d, 2,2,2-trifluoroethanol, pure water and D2O has been determined. Preparation of 4-morpholinecarbonyl chloride has been reported.

Application

4-Morpholinecarbonyl chloride may be used in the preparation of a versatile fluorogenic label for biomolecular imaging. It may be used in the synthesis of:
  • morpholine-4-carboxylic acid [4-(2,4-dimethylphenyl)thiazol-2-yl]amide
  • morpholine-4-carboxylic acid [4-(2,4,6-trimethylphenyl)thiazol-2-yl]amide
  • 2-isopropyl-6-methylpyrimidin-4-yl morpholine-4-carboxylate

pictograms

Exclamation markHealth hazard

signalword

Warning

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2

supp_hazards

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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