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387649

Sigma-Aldrich

N,N-Diisopropylethylamine

purified by redistillation, 99.5%

Synonym(s):

N-Ethyldiisopropylamine, DIPEA, Ethyldiisopropylamine, ‘Hünig’s base’

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About This Item

Linear Formula:
[(CH3)2CH]2NC2H5
CAS Number:
Molecular Weight:
129.24
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.21

Pricing and availability is not currently available.

vapor pressure

31 mmHg ( 37.7 °C)

Quality Level

assay

99.5%

form

liquid

purified by

redistillation

refractive index

n20/D 1.414 (lit.)

bp

127 °C (lit.)

mp

<−50 °C (lit.)

solubility

water: soluble 4.01 g/L at 20 °C

density

0.742 g/mL at 25 °C (lit.)

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1 of 4

This Item
C9697C0255C0130
biological source

Clostridium histolyticum

biological source

Clostridium histolyticum

biological source

-

biological source

-

specific activity

≥125 CDU/mg solid (CDU = collagen digestion units), 0.5-5.0 FALGPA units/mg solid

specific activity

≥800 units/mg solid

specific activity

≥500 CDU/mg solid (CDU = collagen digestion units)

specific activity

≥125 CDU/mg solid

form

lyophilized powder

form

lyophilized powder (from 0.2 μm filtered solution)

form

lyophilized powder

form

lyophilized powder

concentration

1 mg/mL

concentration

1 mg/mL

concentration

-

concentration

-

pH

6.3-8.8

pH

7.4

pH

-

pH

-

General description

N,N-diisopropylethylamine is an aliphatic sterically hindered[1] amine.

Application

N,N-diisopropylethylamine may be used in the following processes:
  • As an organic base in the synthesis of indenopyrones.[2]
  • As an activator for chiral iridium N, P ligand complexes which can be utilized in the hydrogenation of α,β-unsaturated nitriles.[3]
  • As a non-nucleophilic base for substitution reaction.[4]
  • As a starting material in the preparation of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrroles.[5]

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.1 °F

flash_point_c

9.5 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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Enantioselective N-heterocyclic carbene-catalyzed synthesis of indenopyrones.
Chen KQ, et al.
Organic & Biomolecular Chemistry (2015)
Selective Syntheses of Bis [1, 2] dithiolo [1, 4] thiazines and Bis [1, 2] dithiolopyrroles from Hunig's Base.
Rees CW, et al.
The Journal of Organic Chemistry, 63(7), 2189-2196 (1998)
Asymmetric Hydrogenation of α, β-Unsaturated Nitriles with Base-Activated Iridium N, P Ligand Complexes.
Muller MA and Pfaltz A.
Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 126(33), 8812-8815 (2014)
Sequential Michael Addition and Enamine-Promoted Inverse Electron Demanding Diels-Alder Reaction upon 3-Vinyl-1,2,4-triazine Platforms.
Lorion M, et al.
Organic Letters (2015)
Facile and Gram-scale Synthesis of Metal-free Catalysts: Toward Realistic Applications for Fuel Cells.
Kim OH, et al.
Scientific Reports, 5 (2015)

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