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678023

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4,7-Dimethoxy-1,10-phenanthroline

97%

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Synonym(s):
4,7-Dimethoxy-1,10-phenanthrolin
Empirical Formula (Hill Notation):
C14H12N2O2
CAS Number:
Molecular Weight:
240.26
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

97%

form

solid

reaction suitability

reagent type: ligand

mp

197-212 °C

SMILES string

COc1ccnc2c1ccc3c(OC)ccnc23

InChI

1S/C14H12N2O2/c1-17-11-5-7-15-13-9(11)3-4-10-12(18-2)6-8-16-14(10)13/h3-8H,1-2H3

InChI key

ZPGVCQYKXIQWTP-UHFFFAOYSA-N

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This Item
63150713137733510
4,7-Dimethoxy-1,10-phenanthroline 97%

678023

4,7-Dimethoxy-1,10-phenanthroline

1,10-Phenanthrolin-5-amine 97%

631507

1,10-Phenanthrolin-5-amine

1,10-Phenanthroline ≥99%

131377

1,10-Phenanthroline

1,10-Phenanthroline monohydrate ACS reagent, puriss. p.a., ≥99.5% (calc. to the dried substance), for redox titration

33510

1,10-Phenanthroline monohydrate

reaction suitability

reagent type: ligand

reaction suitability

-

reaction suitability

-

reaction suitability

-

form

solid

form

-

form

powder

form

-

mp

197-212 °C

mp

254-258 °C (lit.)

mp

114-117 °C (lit.)

mp

100-104 °C (lit.), 97-102 °C

General description

4,7-Dimethoxy-1,10-phenanthroline is an organic compound that is used as an efficient ligand in organic synthesis. It is used in the N-arylation of imidazole with aryl iodides and bromides in the presence of copper catalysts. Various hindered and functionalized imidazoles and aryl halides were converted using this catalyst.

Application

Ligand for Cu-catalzyed N-arylation of imidazoles

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Customers Also Viewed

Ryan A Altman et al.
Organic letters, 9(4), 643-646 (2007-02-09)
With use of Cu-based catalysts, 2- and 4-hydroxypyridines were N-arylated in modest to excellent yields. In the case of 2-hydroxypyridine, the use of 4,7-dimethoxy-1,10-phenanthroline, 3, expanded the scope of previous literature reports to include the use of N-containing heteroaryl halides
Li, C. S.; Dixon, D. D.
Tetrahedron Letters, 45, 4257-4257 (2004)
Artis Klapars et al.
Journal of the American Chemical Society, 124(25), 7421-7428 (2002-06-20)
An experimentally simple and inexpensive catalyst system was developed for the amidation of aryl halides by using 0.2-10 mol % of CuI, 5-20 mol % of a 1,2-diamine ligand, and K(3)PO(4), K(2)CO(3), or Cs(2)CO(3) as base. Catalyst systems based on
Ryan A Altman et al.
Organic letters, 8(13), 2779-2782 (2006-06-16)
[reaction: see text] 4,7-Dimethoxy-1,10-phenanthroline (L) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazole with aryl iodides and bromides under mild conditions. A variety of hindered and functionalized imidazoles and aryl halides were transformed in good
Ryan A Altman et al.
The Journal of organic chemistry, 72(16), 6190-6199 (2007-07-13)
4,7-Dimethoxy-1,10-phenanthroline (L1c) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazoles and benzimidazoles with both aryl iodides and bromides under mild conditions. Further optimization of the system has revealed that the addition of poly(ethylene glycol) accelerates

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