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Sigma-Aldrich

Poly(N-isopropylacrylamide-co-methacrylic acid)

methacrylic acid 10 mol %, Mn 60,000

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Synonym(s):
Poly(NIPAM-co-MAA), Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM
Linear Formula:
(C6H11NO)m (C4H6O2)n
CAS Number:
NACRES:
NA.23

form

solid

Quality Level

mol wt

Mn 60,000

composition

methacrylic acid, 10 mol %

mp

>300 °C

Mw/Mn

≤2.5

InChI

1S/C6H11NO.C4H6O2/c1-4-6(8)7-5(2)3;1-3(2)4(5)6/h4-5H,1H2,2-3H3,(H,7,8);1H2,2H3,(H,5,6)

InChI key

BGJOTKHBFYMJST-UHFFFAOYSA-N

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This Item
724823724831724807
mp

>300 °C

mp

-

mp

-

mp

>300 °C

mol wt

Mn 60,000

mol wt

Mn 2000-3000 (by HCL Titration)

mol wt

average Mn 5,500 (HCl titration)

mol wt

average Mn 5,000

composition

methacrylic acid, 10 mol %

composition

-

composition

-

composition

-

Mw/Mn

≤2.5

Mw/Mn

-

Mw/Mn

-

Mw/Mn

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Application

Intelligent Swelling/Collapsing copolymer that can be used as a temperature- and pH-sensitive materials.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Pierre Simard et al.
International journal of pharmaceutics, 381(2), 86-96 (2009-05-19)
A promising avenue in cancer therapy using liposomal formulations is the combination of site-specific delivery with triggered drug release. The use of trigger mechanisms in liposomes could be relevant for drugs susceptible to lysosomal hydrolytic/enzymatic degradation. Here, we propose a
Samer R Abulateefeh et al.
Macromolecular bioscience, 11(12), 1722-1734 (2011-10-21)
Many difficulties in treating cancer arise from the problems in directing highly cytotoxic agents to the deseased tissues, cells and intracellular compartments. Many drug delivery systems have been devised to address this problem, including those that show a change in
J Moselhy et al.
Journal of biomaterials science. Polymer edition, 11(2), 123-147 (2000-03-16)
The pH- and temperature-responsive poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAm/MAA) nanoparticles are of potential application in targeted drug delivery. Their responsive properties in the presence of human serum albumin were investigated using dynamic light scattering (DLS), protein assay, and electron spin resonance (ESR)
Weitai Wu et al.
Biosensors & bioelectronics, 25(12), 2603-2610 (2010-05-18)
A new class of optical glucose nanobiosensors with high sensitivity and selectivity at physiological pH is described. To construct these glucose nanobiosensors, the fluorescent CdS quantum dots (QDs), serving as the optical code, were incorporated into the glucose-sensitive poly(N-isopropylacrylamide-acrylamide-2-acrylamidomethyl-5-fluorophenylboronic acid)
Sabrina Schmidt et al.
Langmuir : the ACS journal of surfaces and colloids, 27(16), 9801-9806 (2011-07-09)
Charged poly(N-isopropylacrylamide-co-methacrylic acid) [P(NiPAM-co-MAA)] microgels can stabilize thermo- and pH-sensitive emulsions. By placing charged units at different locations in the microgels and comparing the emulsion properties, we demonstrate that their behaviors as emulsion stabilizers are very different from molecular surfactants

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