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Sigma-Aldrich

α-Ketoglutaric acid disodium salt dihydrate

≥98.0% (dried material, NT)

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Synonym(s):
2-Oxoglutaric acid disodium salt, Sodium α-ketoglutarate dibasic
Linear Formula:
NaOOCCH2CH2COCOONa · 2H2O
CAS Number:
Molecular Weight:
226.09
Beilstein/REAXYS Number:
5658566
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

≥98.0% (dried material, NT)

form

powder

impurities

~16% water

SMILES string

O.O.[Na+].[Na+].[O-]C(=O)CCC(=O)C([O-])=O

InChI

1S/C5H6O5.2Na.2H2O/c6-3(5(9)10)1-2-4(7)8;;;;/h1-2H2,(H,7,8)(H,9,10);;;2*1H2/q;2*+1;;/p-2

InChI key

HSSWOFWCOAQLHZ-UHFFFAOYSA-L

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1 of 4

This Item
K2010K187571995
vibrant-m

K2010

α-Ketoglutaric acid sodium salt

Premium Grade
vibrant-m

K1875

α-Ketoglutaric acid sodium salt

-
vibrant-m

71995

Sodium tartrate dibasic dihydrate

-
Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

200

form

powder

form

powder

form

powder

form

solid

impurities

~16% water

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

impurities

-

impurities

-

General description

α-Ketoglutaric acid disodium salt dihydrate (2-Oxoglutaric acid disodium salt) is the hydrated disodium salt of 2-oxoglutaric acid.

Application

α-Ketoglutaric acid disodium salt dihydrate (2-Oxoglutaric acid disodium salt) may be used as starting reagent for the synthesis of deuteriated 2-oxo[3,3-2H2]glutarate disodium salt.
α-Ketoglutaric acid disodium salt dihydrate is suitable reagent used in a study to investigate the role of nitric oxide (NO) in mast cell physiology and biochemistry.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Kisakurek MV.
Hominatio: An International Tribute to Albert Eschenmoser, 2557-2557 (2001)
Li-Li Chen et al.
Journal of molecular modeling, 19(4), 1919-1927 (2013-01-23)
Bacillus subtilis natto is widely used in industry to produce natto, a traditional and popular Japanese soybean food. However, during its secondary fermentation, high amounts of ammonia are released to give a negative influence on the flavor of natto. Glutamate
Sylwia Magiera et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 919-920, 20-29 (2013-02-16)
A simple, accurate and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantitation of α-ketoglutaric acid (α-KG), L-carnitine (L-CAR) and acetyl-L-carnitine (acetyl-L-CAR) in human urine as potential biomarkers of cardiovascular disease. The separation was
Piotr Dobrowolski et al.
Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 556-561 (2012-12-12)
Proton-pump inhibitors, such as omeprazole, are widely used in the prevention and treatment of gastroesophageal diseases. However, an association between proton-pump inhibitors and the increased risk of bone fractures has been observed, especially in patients treated for extended periods. Conversely
E Tomaszewska et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 63(5), 547-554 (2012-12-06)
The potential effects of prenatal administration of dexamethasone (DEX) and postnatal treatment with 2-oxoglutaric acid (2-Ox) on postnatal development of connective tissue of farm animals were not examined experimentally. The aim of this study was to establish changes in morphological

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