764698

Poly(L-lactide)

average M_n 20,000, PDI ≤1.1

• Synonym(s): PLA, PLLA, Polylactide, L-Lactide polymer, PLA, Poly(L-Lactic acid)
• Linear Formula: H(C₃H₄O₂)_nOCH₃
• NACRES: NA.23

Properties

• form: solid
• Quality Level: 100
• optical activity: [α]22/D -153°, c = 0.5% in chloroform
• mol wt: average M_n 20,000
• degradation timeframe: >3 years
• transition temp: T_m 167-172 °C
• PDI: ≤1.1
• storage temp.: 2-8°C

Description

General description

Poly (L-lactide) is a semi-crystalline polymer which exhibits strong optical rotation and good mechanical properties. It is mostly used in the synthesis of degradable polymers which are used in orthopaedic devices, in dental applications, as scaffolds for autografted new skin, wound covers, anastomose systems and stents. They are biodegradable since the polyester backbone degrades by simple hydrolysis to form non-toxic compounds.

Application

Used in Drug Delivery including coating nanoparticles. Can be end-group functionalizated or used as a macroinitiator/block precursor.

Features and Benefits

High initial strength, good strength retention and high amount of crystallinity as much as 70% which in turn is responsible for the very slow degradation rate.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable