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765708

Sigma-Aldrich

Gold nanoparticles

15 nm diameter, OD 50, methyl terminated, PEG 5000 coated, dispersion in H2O

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Synonym(s):
Gold nanoparticles OMe terminated, Au NP OMe, Gold Colloid

material

PEG 5000

Quality Level

form

dispersion in H2O
nanoparticles

packaging

poly bottle of 1 mL

OD

50

diameter

15 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

λmax

520 nm

functional group

methoxy

storage temp.

2-8°C

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765325
Gold nanoparticles 15 nm diameter, OD 50, methyl terminated, PEG 5000 coated, dispersion in H2O

765708

Gold nanoparticles

Gold nanoparticles 15 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O

765325

Gold nanoparticles

form

dispersion in H2O, nanoparticles

form

dispersion in H2O, nanoparticles

material

PEG 5000

material

PEG 5000

packaging

poly bottle of 1 mL

packaging

poly bottle of 1 mL

OD

50

OD

50

diameter

15 nm

diameter

15 nm

General description

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. AuNPs are shown to be highly sensitive colloidal biosensors. The poly (ethylene) glycol (PEG) coating on gold nanoparticles helps in the reduction of protein adsorption, reduces nonspecific interactions with cells and greatly improves the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles.PEG layer density depends inversely on the AuNP curvature. AuNPs coated with PEG 5000 exhibited the highest colloidal stability. The methyl group, being hydrophobic acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.

Application

Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also used in biodistribution studies.
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Features and Benefits

PEG decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Xiao-Dong Zhang et al.
International journal of nanomedicine, 6, 2071-2081 (2011-10-07)
Gold nanoparticle toxicity research is currently leading towards the in vivo experiment. Most toxicology data show that the surface chemistry and physical dimensions of gold nanoparticles play an important role in toxicity. Here, we present the in vivo toxicity of
Timothy A Larson et al.
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)

Articles

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