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Sigma-Aldrich

Cy5-azide

95% (HPLC)

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Synonym(s):
Cy5 Azide Fluorescent Probe
Empirical Formula (Hill Notation):
C49H78N8O10S3
Molecular Weight:
1035.39
UNSPSC Code:
12352125
PubChem Substance ID:
329767899
NACRES:
NA.22

Quality Level

100

assay

95% (HPLC)

form

solid

reaction suitability

reaction type: click chemistry

ε (extinction coefficient)

251,000

fluorescence

λex 647 nm; λem 663 nm

storage temp.

−20°C

SMILES string

CC1(C)C(/C=C/C=C/C=C(N2CCCS([O-])(=O)=O)\C(C)(C)C3=C2C=CC(S([O-])(=O)=O)=C3)=[N+](CCCCCC(NCCCN=[N+]=[N-])=O)C4=C1C=C(S([O-])(=O)=O)C=C4.CC[NH+](CC)CC.CC[NH+](CC)CC

InChI

1S/C37H48N6O10S3.2C6H15N/c1-36(2)29-25-27(55(48,49)50)16-18-31(29)42(22-10-6-9-15-35(44)39-20-11-21-40-41-38)33(36)13-7-5-8-14-34-37(3,4)30-26-28(56(51,52)53)17-19-32(30)43(34)23-12-24-54(45,46)47;2*1-4-7(5-2)6-3/h5,7-8,13-14,16-19,25-26H,6,9-12,15,20-24H2,1-4H3,(H3-,39,44,45,46,47,48,49,50,51,52,53);2*4-6H2,1-3H3

InChI key

NJSWGOLBDDXJQO-UHFFFAOYSA-N

Related Categories

Application

Azide modified cyanine dye that can be used to detect or label alkyne- or cyclooctyne-containing molecules or biomolecules by fluorescence spectroscopy following azide-alkyne cycloaddition.

Solubility: DMSO, DMF, MeOH

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Markus Muttenthaler et al.
Australian journal of chemistry, 73(4), 327-333 (2020-05-13)
In-solution conjugation is the most commonly used strategy to label peptides and proteins with fluorophores. However, lack of site-specific control and high costs of fluorophores are recognised limitations of this approach. Here, we established facile access to grams of Cy5-COOH
Shanqiao Wei et al.
PloS one, 12(9), e0185010-e0185010 (2017-09-20)
Most B cell cancers overexpress the enzyme activation-induced deaminase at high levels and this enzyme converts cytosines in DNA to uracil. The constitutive expression of this enzyme in these cells greatly increases the uracil content of their genomes. We show
Tom van der Wel et al.
Nature communications, 11(1), 3216-3216 (2020-06-27)
Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases. By substituting a serine
Valentina M Farzan et al.
Bioconjugate chemistry, 28(10), 2599-2607 (2017-09-19)
We developed a novel technique for the efficient conjugation of oligonucleotides with various alkyl azides such as fluorescent dyes, biotin, cholesterol, N-acetylgalactosamine (GalNAc), etc. using copper-catalysed alkyne-azide cycloaddition on the solid phase and CuI·P(OEt)
Björn Trebels et al.
Scientific reports, 10(1), 1090-1090 (2020-01-25)
Several studies showed adult persisting neurogenesis in insects, including the red flour beetle Tribolium castaneum, while it is absent in honeybees, carpenter ants, and vinegar flies. In our study, we focus on cell proliferation in the adult mushroom bodies of
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