803472
SMPT (4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene)
Synonym(s):
2,5-Dioxo-1-pyrrolidinyl 4-[1-(2-pyridinyldithio)ethyl]benzoate, SMPT
About This Item
Recommended Products
assay
≥90%
Quality Level
form
powder
mol wt
388.46
reaction suitability
reagent type: cross-linking reagent
storage condition
desiccated
solubility
DMSO or DMF: soluble
functional group
NHS ester
shipped in
ambient
storage temp.
2-8°C
SMILES string
O=C(ON1C(CCC1=O)=O)C2=CC=C(C(SSC3=CC=CC=N3)C)C=C2
InChI
1S/C18H16N2O4S2/c1-12(25-26-15-4-2-3-11-19-15)13-5-7-14(8-6-13)18(23)24-20-16(21)9-10-17(20)22/h2-8,11-12H,9-10H2,1H3
InChI key
GKSPIZSKQWTXQG-UHFFFAOYSA-N
Related Categories
General description
Features and Benefits
- Reactive groups: NHS ester and pyridyldithiol
- Reactive towards: amino and sulfhydryl groups
- Cleavable with disulfide reducing agents
- Water-insoluble (dissolve first in DMF or DMSO)
- Contains a hindered disulfide bond; has formed immunotoxins with improved stability
- In vitro, an SMPT conjugate was as effective as conjugates formed with SPDP and 2-IT
- Compare to other varieties of SPDP-type reagents, including pegylated forms
Caution
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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