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81801

Sigma-Aldrich

Propylphosphonic anhydride solution

technical, ~50% in DMF

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Synonym(s):
1-Propanephosphonic anhydride solution, 2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide solution, PPACA, T3P®
Empirical Formula (Hill Notation):
C9H21O6P3
CAS Number:
Molecular Weight:
318.18
Beilstein/REAXYS Number:
5079255
MDL number:
PubChem Substance ID:
NACRES:
NA.22

grade

technical

Quality Level

form

solution

concentration

~50% in DMF

SMILES string

CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1

InChI

1S/C9H21O6P3/c1-4-7-16(10)13-17(11,8-5-2)15-18(12,14-16)9-6-3/h4-9H2,1-3H3

InChI key

PAQZWJGSJMLPMG-UHFFFAOYSA-N

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This Item
431303179728320064
Propylphosphonic anhydride solution technical, ~50% in DMF

81801

Propylphosphonic anhydride solution

Super-Hydride® solution 1.0 M lithium triethylborohydride in THF

179728

Super-Hydride® solution

Phthalic anhydride ACS reagent, ≥99%

320064

Phthalic anhydride

form

solution

form

liquid

form

liquid

form

flakes

grade

technical

grade

-

grade

-

grade

-

concentration

~50% in DMF

concentration

≥50 wt. % in ethyl acetate

concentration

1.0 M lithium triethylborohydride in THF

concentration

-

General description

Propylphosphonic anhydride is a highly reactive cyclic anhydride that is commonly used as a coupling agent and water scavenger.

Application

Coupling reagent for peptide synthesis; Preparation of other amides; Synthesis of esters (depsipeptides)

Features and Benefits

Some of its unique features include:
  • Broad functional group tolerance
  • Low epimerization tendency
  • By-products are water-soluble
  • High yield and purity


Legal Information

T3P is a registered trademark of Archimica GmbH

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1B - Skin Sens. 1

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

143.6 °F

flash_point_c

62 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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Customers Also Viewed

Slide 1 of 6

1 of 6

H. Wissmann
Phosph. Sulfur Relat. Elem., 30, 645-645 (1986)
H. Kessler et al.
Liebigs Ann. Chem., 1-1 (1986)
H. Wissmann et al.
Angewandte Chemie (International Edition in English), 92, 129-129 (1980)
M. Feigel
Journal of the American Chemical Society, 108, 181-181 (1986)
Propylphosphonic anhydride (T3P?): an efficient reagent for the one-pot synthesis of 1, 2, 4-oxadiazoles, 1, 3, 4-oxadiazoles, and 1, 3, 4-thiadiazoles.
Augustine JK, et al.
Tetrahedron, 65(48), 9989-9996 (2009)

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